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公开(公告)号：US20220370716A1
公开(公告)日：2022-11-24
申请号：US17748221
申请日：2022-05-19
发明人： Bryn Martin , Mohammadreza Khani , Lucas Sass , Ostin Arters , Stuart Sater , Deep Arjun Singh , PJ Anand , Thomas T. Washburn , Krishna Subramanian
IPC分类号： A61M5/172 , A61M5/00 , A61K31/713
摘要： The disclosed systems and methods are configurable central nervous system (CNS) delivery solutions for therapeutics, such as genetic medicines. The systems and methods first infuse a therapeutic bolus within intrathecal space and subsequently infuse a flush fluid to move the therapeutic bolus rostrally toward a target area and achieve a desired spread in the spine and/or brain. The second location can be at a location caudal to the delivery location of the therapeutic bolus.
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公开(公告)号：US20230173224A1
公开(公告)日：2023-06-08
申请号：US18095334
申请日：2023-01-10
发明人： PJ Anand , Morgan Brophy , Deep Arjun Singh , Greg Eberl , Ayesha Arzumand , Stela Moura , Andrew East , Jonathan Freund
CPC分类号： A61M25/003 , A61M5/007 , A61M5/168 , A61M5/172 , A61M5/1723 , A61M5/14546 , A61M25/0017 , A61M25/0032 , A61M25/0045 , A61M25/1002 , A61M25/1011 , A61M39/0208 , A61M5/19
摘要： Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient’s natural cerebrospinal fluid (CSF) pulsation or the patient’s heart or respiration rate). In some embodiments, a drug delivery system can be configured to use a combination of infusion and aspiration to control delivery of a drug to a patient. Catheters, controllers, and other components for use in the above systems are also disclosed, as are various methods of using such systems.
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3.发明授权公开(公告)号：US11602375B2
公开(公告)日：2023-03-14
申请号：US16590336
申请日：2019-10-01
发明人： Deep Arjun Singh , P J Anand
摘要： Methods and devices are disclosed herein that generally provide protection for devices (e.g., microcatheters) having small tips. Methods and devices are also disclosed herein that generally facilitate use of commercially-available stereotactic systems with devices (e.g., microcatheters) having small tips.
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公开(公告)号：US11607529B2
公开(公告)日：2023-03-21
申请号：US17588087
申请日：2022-01-28
发明人： Andrew East , Burt Raymond , Andre Carline Wood , Deep Arjun Singh , Jonathan Freund , John L. Mcguire , Krishna Subramanian , Matthew J. Lapinski , Megan Holmes , Thomas T. Washburn
IPC分类号： A61M25/02
摘要： Fixation devices are disclosed herein that can be used to secure to a catheter and to tissue. The fixation devices include a body having a bore extending therethrough to receive a catheter. The fixation devices can also include suture openings or grooves to secure the devices to tissue.
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公开(公告)号：US11534592B2
公开(公告)日：2022-12-27
申请号：US16570493
申请日：2019-09-13
发明人： Deep Arjun Singh , P J Anand , Andrew East
摘要： Systems and methods for delivering a drug or other therapy over an extended period of time (e.g., several hours, days, weeks, months, years, and so forth) are disclosed herein, as are systems and methods for monitoring various parameters associated with the treatment of a patient. Systems and methods are also disclosed herein that generally involve CED devices with various features for reducing or preventing backflow.
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公开(公告)号：US11904128B2
公开(公告)日：2024-02-20
申请号：US17004470
申请日：2020-08-27
发明人： PJ Anand , Deep Arjun Singh , Andrew East , Thomas T. Washburn , Megan Holmes
CPC分类号： A61M39/0208 , A61M2039/0072 , A61M2039/0235 , A61M2039/062 , A61M2039/1033
摘要： The fluid delivery devices, systems and methods described herein include a subcutaneous port, a catheter, and a connection assembly configured to fluidly couple the port and catheter.
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公开(公告)号：US11793974B2
公开(公告)日：2023-10-24
申请号：US16788192
申请日：2020-02-11
发明人： P J Anand , Deep Arjun Singh , Andrew East , Thomas T. Washburn , Rahul Veetekat , Nicole Bettè , Chris Fleege , Matthew J. Lapinski , Burt Raymond
CPC分类号： A61M25/04 , A61M2025/024 , A61M2025/0206 , A61M2025/028 , A61M2025/0246 , A61M2025/0253 , A61M2025/0266 , A61M2025/0286
摘要： Fixation devices are disclosed herein that can be used to secure to a catheter. The fixation devices include a body having a central bore extending therethrough to receive a catheter and at least one end having a tapered profile tapering inwardly a distal edge thereof. The body can include an expanded intermediate portion, such as one or more bulbous portions. The fixation devices can also include suture openings or grooves to secure the devices to tissue.
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公开(公告)号：US20220379010A1
公开(公告)日：2022-12-01
申请号：US17748199
申请日：2022-05-19
发明人： Bryn Martin , Mohammadreza Khani , Lucas Sass , Ostin Arters , Stuart Sater , Deep Arjun Singh , PJ Anand , Thomas T. Washburn , Krishna Subramanian
IPC分类号： A61M5/14 , A61M5/168 , A61M5/00 , A61M5/172 , C12N15/113
摘要： The disclosed systems and methods are configurable central nervous system (CNS) delivery solutions for therapeutics, such as genetic medicines. The systems and methods first infuse a therapeutic bolus within intrathecal space and subsequently infuse a flush fluid to move the therapeutic bolus rostrally toward a target area and achieve a desired spread in the spine and/or brain. The second location can be at a location caudal to the delivery location of the therapeutic bolus.
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公开(公告)号：US11850374B2
公开(公告)日：2023-12-26
申请号：US16896144
申请日：2020-06-08
IPC分类号： A61M25/00 , A61M5/172 , A61M5/145 , A61M5/00 , A61M5/168 , A61M25/10 , A61M39/02 , A61M5/19 , A61M25/01 , A61M25/09 , C12N15/113 , C12N15/11
CPC分类号： A61M25/003 , A61M5/007 , A61M5/14546 , A61M5/168 , A61M5/172 , A61M5/1723 , A61M25/0017 , A61M25/0032 , A61M25/0045 , A61M25/1002 , A61M25/1011 , A61M39/0208 , A61M5/19 , A61M25/0147 , A61M25/09 , A61M2005/1726 , A61M2025/0007 , A61M2025/1052 , A61M2205/0266 , A61M2205/3303 , A61M2205/3331 , A61M2205/3584 , A61M2205/502 , A61M2205/52 , A61M2210/0693 , A61M2210/1003 , A61M2230/06 , A61M2230/42 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2320/32 , C12N2320/35
摘要： A therapy specific, pre-programmed, hand-held auto-injection device for delivering a drug to a patient includes a housing, a plurality of syringes carried by the housing, at least one actuator disposed within the housing coupled to the plurality of syringes, and a controller disposed within the housing and communicatively coupled to the at least one actuator. The controller is configured to receive an infusion and aspiration profile, which includes an infusion and aspiration protocol for controlling at least one of the plurality of syringes. The controller is also configured to operate the at least one actuator based on the infusion and aspiration protocol by either expelling a fluid from a respective barrel of the plurality of syringes into the infusion and aspiration location or drawing a fluid from the infusion and aspiration location into a respectively barrel of the plurality of syringes.
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公开(公告)号：US20220370710A1
公开(公告)日：2022-11-24
申请号：US17748246
申请日：2022-05-19
发明人： Bryn Martin , Mohammadreza Khani , Lucas Sass , Ostin Arters , Stuart Sater , Deep Arjun Singh , Pj Anand , Thomas T. Washburn , Krishna Subramanian
摘要： The disclosed systems and methods are configurable central nervous system (CNS) delivery solutions for therapeutics, such as genetic medicines. The systems and methods first infuse a therapeutic bolus within intrathecal space and subsequently infuse a flush fluid to move the therapeutic bolus rostrally toward a target area and achieve a desired spread in the spine and/or brain. The second location can be at a location caudal to the delivery location of the therapeutic bolus.
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