公开(公告)号：US3922265A

公开(公告)日：1975-11-25

申请号：US43396774

申请日：1974-01-16

Applicant: ALLIED CHEM

Inventor： FUHRMANN ROBERT ,  TUNICK ALLEN A ,  SIFNIADES STYLIANOS

IPC: C07D223/12 ,  C07D211/56 ,  C07D211/76 ,  C07D223/10

CPC classification number: C07D211/56 ,  C07D211/76

Abstract: Alpha -amino- delta -valerolactam and Alpha -amino- Epsilon caprolactam are produced by contacting the corresponding Alpha aminocycloalkanone oxime or mineral acid salt thereof with liquid SO2 containing at least about 1 mole SO3 per mole Alpha aminocycloalkanone oxime until a two-phase system comprising a liquid SO2 phase and an insoluble lactam precursor phase is formed; separating the liquid SO2 phase from the insoluble phase containing the lactam precursor; hydrolyzing and neutralizing the insoluble lactam precursor phase and recovering the free lactam product.

Abstract translation: α-氨基-δ-戊内酰胺和α-氨基 - ε-己内酰胺是通过使相应的α-氨基环烷酮肟或其无机酸盐与每摩尔α-氨基环烷酮肟含有至少约1摩尔SO 3的液体SO 2接触， 形成包含液体SO 2相和不溶性内酰胺前体相的相体系; 将液体SO 2相从含有内酰胺前体的不溶相分离; 水解和中和不溶性内酰胺前体相并回收游离的内酰胺产物。

公开(公告)号：US3862985A

公开(公告)日：1975-01-28

申请号：US39110073

申请日：1973-08-27

Applicant: ALLIED CHEM

Inventor： SIFNIADES STYLIANOS ,  FUHRMANN ROBERT ,  TUNICK ALLEN A

IPC: C07C237/00 ,  C07D207/28 ,  C07C103/00

CPC classification number: C07D207/28 ,  C07C237/00

Abstract: L-lysineamide dihydrochloride can be isolated by preparing the intermediate D- and L-lysineamide-L-pyrrolidone carboxylate hydrochloride salts which can be separated from alkanol solution by fractional crystallization. The L-lysineamide pyrrolidone carboxylate hydrochloride salt is then treated with excess hydrogen chloride to form the desired L-lysineamide dihydrochloride.

Abstract translation: 可以通过制备中间体D-和L-赖氨酰胺-L-吡咯烷酮羧酸盐酸盐盐分离L-赖氨酰胺二盐酸盐，其可以通过分级结晶与烷醇溶液分离。 然后用过量的氯化氢处理L-赖氨酰胺吡咯烷酮羧酸盐酸盐，形成所需的L-赖氨酰胺二盐酸盐。