公开(公告)号：US20240101710A1

公开(公告)日：2024-03-28

申请号：US18468854

申请日：2023-09-18

Applicant: ALLOGENE THERAPEUTICS, INC. ,  PFIZER INC.

Inventor： Zea Melton ,  Tao Sai ,  Thomas John Van Blarcom

IPC: C07K16/42 ,  A61K49/00 ,  C07K1/22 ,  C07K16/28 ,  C12N5/0783 ,  G01N33/569

CPC classification number: C07K16/4266 ,  A61K49/0058 ,  C07K1/22 ,  C07K16/2878 ,  C12N5/0636 ,  G01N33/56972 ,  C07K2317/622 ,  C12N2501/998

Abstract: Provided herein are anti-idiotype antibodies that specifically recognize anti-BCMA antibody moieties, in particular, anti-BCMA antibody moieties present in recombinant receptors, including chimeric antigen receptors (CARs). The disclosure further relates to uses of anti-idiotype antibodies for specifically identifying and/or selecting cells expressing such recombinant receptors, such as anti-BCMA CAR T cells. The disclosure further relates to uses of anti-idiotype antibodies for specifically activating such cells.

公开(公告)号：US11732041B2

公开(公告)日：2023-08-22

申请号：US16851691

申请日：2020-04-17

Applicant: ALLOGENE THERAPEUTICS, INC.

Inventor： Thomas Charles Pertel ,  Barbra Johnson Sasu ,  Tao Sai

IPC: C07K16/28 ,  C07K16/42 ,  A61K35/17

CPC classification number: C07K16/2803 ,  A61K35/17 ,  C07K16/4241 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92

Abstract: Provided herein are isolated antibodies that specifically bind anti-CD19 chimeric antigen receptors (CARs) derived from a 4G7 scFv. Also provided are methods of making and using these isolated antibodies.