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1.发明申请SALTS OF 2-AMINO-1-HYDROXYETHYL-8-HYDROXYQUINOLIN-2(1H)-ONE DERIVATIVES HAVING BOTH MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITIES 有权具有两种MUSCARINIC受体拮抗剂和BETA2 ADRENERGIC受体激动剂活性的2-氨基-1-羟基乙基-8-羟基喹啉-2（1H） - 酮衍生物的盐公开(公告)号：US20160166566A1
公开(公告)日：2016-06-16
申请号：US14906991
申请日：2014-07-24
Applicant: ALMIRALL, S.A.
Inventor： Montserrat JULIA JANE , Francesc CARRERA CARRERA , Maria PRAT QUIÑONES , Carlos PUIG DURAN , Francesca PAJUELO LORENZO , Juan Antonio PEREZ ANDRES
IPC: A61K31/4709 , A61K9/00 , A61K45/06
CPC classification number: A61K31/4709 , A61K9/0075 , A61K9/008 , A61K31/4725 , A61K45/06 , C07B2200/13 , C07C57/15 , C07D275/06 , C07D409/14 , C07D417/14 , A61K2300/00
Abstract: The present invention is directed to crystalline addition salts of (ii) 8-hydroxyquinolin-2(1H)-one derivatives and (ii) a dicarboxylic acid or a sulfimide, or a pharmaceutically acceptable solvates thereof.
Abstract translation: 本发明涉及（ii）8-羟基喹啉-2（1H） - 酮衍生物和（ii）二羧酸或硫酰亚胺或其药学上可接受的溶剂合物的结晶加成盐。
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2.发明申请SALTS OF 2-AMINO-1-HYDROXYETHYL-8-HYDROXYQUINOLIN-2(1H)-ONE DERIVATIVES HAVING BOTH β2 ADRENERGIC RECEPTOR AGONIST AND M3 MUSCARINIC RECEPTOR ANTAGONIST ACTIVITIES 有权2-氨基-1-羟基乙基-8-羟基喹啉-2（1H） - 酮衍生物，具有两种和两种ADRENERGIC受体激动剂和M3MUSCARINIC受体拮抗剂活性公开(公告)号：US20160009698A1
公开(公告)日：2016-01-14
申请号：US14770206
申请日：2014-02-27
Applicant: ALMIRALL S.A.
Inventor： Montserrat JULIA JANE , Francesc CARRERA CARRERA , Maria PRAT QUIÑONES , Carlos PUIG DURAN , Francesca PAJUELO LORENZO , Juan Antonio PEREZ ANDRES
IPC: C07D409/14 , C07C309/05 , A61K9/00 , C07C59/255 , A61K31/4709 , A61K45/06 , C07D275/06
CPC classification number: C07D409/14 , A61K9/0073 , A61K9/0075 , A61K31/4709 , A61K45/06 , C07B2200/13 , C07C59/255 , C07C309/05 , C07D275/06 , A61K2300/00
Abstract: The present invention is directed to crystalline addition salts of (i) 8-hydroxyquinolin-2(1H)-one derivatives and (ii) a hydroxycarboxylic acid, a sulfonic acid or a sulfimide, or a pharmaceutically acceptable solvates thereof.
Abstract translation: 本发明涉及（i）8-羟基喹啉-2（1H） - 酮衍生物和（ii）羟基羧酸，磺酸或硫酰亚胺或其药学上可接受的溶剂合物的结晶加成盐。
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