公开(公告)号：US3845770A

公开(公告)日：1974-11-05

申请号：US25946972

申请日：1972-06-05

Applicant: ALZA CORP

Inventor： THEEUWES F ,  HIGUCHI T

IPC: A01N25/34 ,  A61F6/14 ,  A61F9/00 ,  A61K9/00 ,  B01J4/04 ,  A61M31/00

CPC classification number: A61F6/144 ,  A61F9/0017 ,  A61K9/0004

Abstract: A wall surrounding and forming a compartment for containing a useful composition of matter and having a passageway for dispensing the composition is disclosed. The wall is comprised in at least a part of a material permeable to an external fluid. The composition is soluble in the fluid and exhibits an osmotic pressure gradient against the fluid or the composition has limited solubility and is admixed with an osmotically effective compound soluble in the fluid that exhibits an osmotic pressure gradient against the fluid. In operation, composition is dispensed from the device by fluid permeating into the compartment producing a solution of the soluble composition or a solution of the osmotically effective compound containing the composition, which solution in either operation is released through the passageway to the exterior of the device at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall of the device.

Abstract translation: 公开了围绕并形成用于容纳物质的有用组合物并具有用于分配组合物的通道的隔室的壁。 所述壁包括在可渗透外部流体的材料的至少一部分中。 该组合物可溶于流体并且表现出对流体的渗透压梯度或组合物具有有限的溶解度，并且与可溶于流体的渗透压有效的化合物混合，该化合物对流体表现出渗透压梯度。 在操作中，组合物通过流体渗透到隔室中从装置中分配，产生可溶性组合物或含有组合物的渗透有效化合物的溶液的溶液，该溶液在任一操作中通过通道释放到装置的外部 以由壁的渗透性和穿过该装置的壁的渗透压梯度控制的速率。

公开(公告)号：US3760984A

公开(公告)日：1973-09-25

申请号：US3760984D

申请日：1971-09-29

Applicant: ALZA CORP

Inventor： THEEUWES F

IPC: A61K9/00 ,  B01J4/04 ,  B65D37/00 ,  B65D35/28

CPC classification number: B01D61/002 ,  A61K9/0004 ,  B01D61/005

Abstract: A device is disclosed comprised of a wall formed of a material collapsable in response to mechanical force and surrounding a closed compartment for containing an agent, a dispensing passageway communicates with the compartment and the exterior of the device for dispensing agent therefrom, a filling passageway communicates with the exterior of the device and the compartment for filling the device, a layer of an osmotically effective solute is deposited on the collapsable wall''s outer surface, said solute capable of exhibiting an osmotic pressure gradient against an external fluid and increasing its volume as fluid diffuses by osmosis into the solute, an outer wall surrounding the layer of solute formed of a material having shape retaining properties, permeable to the fluid and substantially impermeable to solute, and wherein the filling passageway houses a material penetrable to a means for filling the compartment which material self closes on removal of the means to maintain the compartment in closed condition for subsequent collapsing thereof in response to mechanical or hydrostatic force generated by osmotic pressure arising in the solute layer, as fluid diffuses therein to increase its volume and generate forces that are exerted between the collapsable wall of the agent containing chamber and the more rigid outer semi-permeable wall, which collapsing force in turn dispenses an agent through the dispensing passageway when the compartment is charged with drug and the device is positioned in the environment of use.

Abstract translation: 公开了一种装置，其包括由能够响应于机械力而可折叠并且围绕用于容纳试剂的封闭隔室的材料形成的壁，分配通道与该隔室和用于分配剂的装置的外部连通，填充通道连通 随着装置的外部和用于填充装置的隔室，一层渗透性有效的溶质沉积在可塌缩的壁的外表面上，所述溶质能够显示针对外部流体的渗透压梯度并随着流体扩散而增加其体积 通过渗透到溶质中，围绕溶质层的外壁由具有形状保持性质的材料形成，其具有可渗透的流体并且基本上不可渗透溶解，并且其中填充通道容纳可渗透到用于填充隔室的装置的材料， 材料自动关闭，以取消维护比较的手段 由于流体在其中扩散以增加其体积并且产生施加在药剂容纳室的可塌缩壁之间的力并且产生的作用力在闭合状态下随后塌陷，以随着溶质层中产生的渗透压产生的机械静力或静水力， 更刚性的外部半透水壁，当隔室装满药物并且该装置位于使用环境中时，该塌缩力又通过分配通道分配药剂。