公开(公告)号：US3787571A

公开(公告)日：1974-01-22

申请号：US3787571D

申请日：1971-11-11

Applicant: ALZA CORP

Inventor： HIGUCHI T

IPC: A61K9/00 ,  A61K47/10 ,  A61K17/00

CPC classification number: A61K9/0014 ,  A61K47/10

Abstract: DERMAL COMPOSITIONS ARE DISCLOSED WHICH COMPRISE TRICHLOROETHANOL OR TRIFLUOROETHANOL AS ONE COMPONENT OF A VEHICLE HAVING SOLUBILIZED THEREIN A DRUG OR OTHER BENEFICIAL CHEMICAL COMPOUND. ALSO DISCLOSED IS A METHOD FOR ADMINISTERING A DRUG OR OTHER BENEFICIAL CHEMICAL COMPOUND TO THE BODY WHICH COMPRISES CONTACTING THE SKIN WITH THE DRUG OR COMPOUND IN THE PRESENCE OF TRICHLOROETHANOL OR TRIFLUOROETHANOL WHIC ACTS AS AN ABSORPTION PROMOTER TO ENHANCE THE TOPICAL OR PERCUTANEOUS ABSORPTION OF THE ACTIVE DRUG OR COMPOUND.

公开(公告)号：US3710795A

公开(公告)日：1973-01-16

申请号：US3710795D

申请日：1970-09-29

Applicant: ALZA CORP

Inventor： HIGUCHI T ,  LEEPER H

IPC: A61D7/00 ,  A61K9/22 ,  A61M31/00 ,  A61M7/00 ,  A61J1/00

CPC classification number: A61M31/002 ,  A61D7/00

Abstract: Drug-delivery device for releasing drug at a controlled rate for a prolonged period of time is formed from a solid inner matrix material having drug dispersed therethrough. Surrounding the inner matrix is an intimately contacting outer polymeric membrane, insoluble in body fluids, which contracts about the matrix as the matrix decreases in volume upon drug release. Both the inner matrix material and the outer polymeric membrane are permeable to passage of the drug by diffusion but the drug diffuses through the outer polymer membrane at a lesser rate so that passage through the polymeric membrane is the drug release rate controlling step. The integrity of the intimate contact between the membrane and the matrix is assured even upon matrix depletion immediately following manufacture and for an extended period of time by reason of the reserve elastic recovery stress in the membrane.

Abstract translation: 药物释放装置以较长的时间以受控的速率释放药物由具有分散在其中的药物的固体内基质材料形成。 内部基质周围是紧密接触的外部聚合物膜，不溶于体液，当药物释放时基质随着基体体积的减小而收缩。 内部基质材料和外部聚合物膜均可通过扩散使药物通过，但是药物以较低的速率扩散通过外部聚合物膜，使得通过聚合物膜是药物释放速率控制步骤。 膜和基质之间的紧密接触的完整性即使在制造后立即消耗基质并由于膜中储备弹性恢复应力而延长的时间段也是可以确保的。

公开(公告)号：US3760805A

公开(公告)日：1973-09-25

申请号：US3760805D

申请日：1971-01-13

Applicant: ALZA CORP

Inventor： HIGUCHI T

IPC: A01G7/06 ,  A61D7/00 ,  A61K9/00 ,  A61K9/22 ,  B01J4/04 ,  B65D1/04 ,  A61M31/00

CPC classification number: A01G7/06 ,  A61D7/00 ,  A61K9/0004 ,  B01J4/04 ,  B65D1/04

Abstract: An osmotic dispenser is comprised of (1) a water porous housing member confining (2) a first flexible bag of relatively impervious material containing an active agent and provided with active agent dispensing head, and (3) a second bag of controlled permeability to moisture containing a solution which exhibits an osmotic pressure gradient against water. The first and second bags are disposed within the housing member such that water permeates from the external environment through the housing and migrates by osmosis into the solution contained in the second bag which increases in volume thereby generating mechanical force on the first bag, which mechanical force in turn ejects the active agent out of the apparatus.

Abstract translation: 渗透分配器包括（1）水多孔壳体构件，其限定（2）包含活性剂并具有活性剂分配头的相对不透水材料的第一柔性袋，以及（3）第二袋， 含有对水表现出渗透压梯度的溶液。 第一袋和第二袋设置在壳体构件内，使得水从外部环境通过壳体渗透并通过渗透迁移到容纳在第二袋中的溶液中，从而在第一袋上产生机械力，该机械力 反过来将活性剂排出设备。

公开(公告)号：US3845770A

公开(公告)日：1974-11-05

申请号：US25946972

申请日：1972-06-05

Applicant: ALZA CORP

Inventor： THEEUWES F ,  HIGUCHI T

IPC: A01N25/34 ,  A61F6/14 ,  A61F9/00 ,  A61K9/00 ,  B01J4/04 ,  A61M31/00

CPC classification number: A61F6/144 ,  A61F9/0017 ,  A61K9/0004

Abstract: A wall surrounding and forming a compartment for containing a useful composition of matter and having a passageway for dispensing the composition is disclosed. The wall is comprised in at least a part of a material permeable to an external fluid. The composition is soluble in the fluid and exhibits an osmotic pressure gradient against the fluid or the composition has limited solubility and is admixed with an osmotically effective compound soluble in the fluid that exhibits an osmotic pressure gradient against the fluid. In operation, composition is dispensed from the device by fluid permeating into the compartment producing a solution of the soluble composition or a solution of the osmotically effective compound containing the composition, which solution in either operation is released through the passageway to the exterior of the device at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall of the device.

Abstract translation: 公开了围绕并形成用于容纳物质的有用组合物并具有用于分配组合物的通道的隔室的壁。 所述壁包括在可渗透外部流体的材料的至少一部分中。 该组合物可溶于流体并且表现出对流体的渗透压梯度或组合物具有有限的溶解度，并且与可溶于流体的渗透压有效的化合物混合，该化合物对流体表现出渗透压梯度。 在操作中，组合物通过流体渗透到隔室中从装置中分配，产生可溶性组合物或含有组合物的渗透有效化合物的溶液的溶液，该溶液在任一操作中通过通道释放到装置的外部 以由壁的渗透性和穿过该装置的壁的渗透压梯度控制的速率。

公开(公告)号：US3732865A

公开(公告)日：1973-05-15

申请号：US3732865D

申请日：1971-01-13

Applicant: ALZA CORP

Inventor： HIGUCHI T ,  LEEPER H

IPC: A61F6/14 ,  A61K9/00 ,  A61M7/00 ,  A61M31/00

CPC classification number: A61K9/0004 ,  A61F6/14

Abstract: An osmotic active agent dispenser is comprised of (1) a first compartment of relatively impervious material containing an active agent and provided with an aperture for releasing said active agent to the exterior of the dispenser; (2) a second compartment of controlled permeability to water containing a solution of an osmotically effective solute which exhibits an osmotic pressure gradient against water; and (3) a movable barrier member separating the first from the second compartment. The barrier member is slidably responsive to an increase in volume in the second compartment via absorption of water therein; whereby as water flows by osmosis into the compartment (2) of the dispenser in a tendency towards osmotic equilibrium with its environment, corresponding pressure is exerted behind the barrier (3) driving it into and diminishing the volume of the compartment (1), in turn continuously ejecting active agent thereout at an osmotically controlled rate over a prolonged period of time. In a specific embodiment, the dispenser is comprised of a plurality of capsule half shells one of which compartmentalizing and being free to move within the device, thereby defining a closure for both the active agent compartment and the solution compartment.

Abstract translation: 渗透活性剂分配器包括（1）含有活性剂的相对不可渗透材料的第一隔室，并设置有用于将所述活性剂释放到分配器外部的孔; （2）具有受渗透性的第二隔室，其含有渗透压梯度对水的渗透有效溶质的溶液; 和（3）将第一与第二隔室分开的可动阻挡件。 阻挡构件通过其中的水的吸收可滑动地响应于第二隔室中的体积增加; 由此随着水以与其环境渗透平衡的趋势渗透进入分配器的隔室（2）中，在屏障（3）的后面施加相应的压力，将其驱动并减小隔间（1）的体积， 在延长的时间内以渗透控制的速率连续喷射活性剂。 在具体实施例中，分配器由多个胶囊半壳构成，其中一个壳体间隔开并在装置内自由移动，从而为活性剂隔室和溶液隔室两者限定封闭件。

公开(公告)号：US3729947A

公开(公告)日：1973-05-01

申请号：US3729947D

申请日：1970-12-04

Applicant: ALZA CORP

Inventor： HIGUCHI T

IPC: A61K31/557 ,  B65B63/08 ,  A61K17/00 ,  C12K9/00

CPC classification number: A61K31/557

Abstract: A process for storing blood platelets while simultaneously preserving the viability and integrity of the platelets by maintaining the platelets at a pressure of 100 to 1,000 psi and at a temperature of just above the freezing temperature of the platelets to about ambient temperature. The platelets may be stored alone or with platelet preserving agents.

Abstract translation: 一种用于储存血小板的方法，同时通过将血小板保持在100-1000psi的压力和刚刚高于血小板的冷冻温度的温度至约环境温度来保持血小板的活力和完整性。 血小板可以单独储存或与血小板保存剂一起储存。

公开(公告)号：US3792081A

公开(公告)日：1974-02-12

申请号：US3792081D

申请日：1972-04-07

Applicant: ALZA CORP

Inventor： HIGUCHI T ,  STELLA V

IPC: C07C275/24 ,  C07D263/44 ,  C07C127/18

CPC classification number: C07D263/44 ,  C07C275/24

Abstract: NOVEL ESTER OF SUBTITUTED HYDANTOIC ACIDS OF THE FORMAL:

R1-NH-CO-N(-R2)-C(-R3)(-R4)-COO-ALK-N(-R5)-R6

WHEREIN R1 AND R2 ARE HYDROGEN OR ALKYL, R3 AND R4 ARE HYDROGEN, ALKYL OR PHENYL, R5 AND R6 ARE HYDROGEN OR ALKYL, ALK IS ALKYLENE AND THE PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF. THE COMPOUNDS OF THE FORMULA ARE USEFUL AS ANTICONVULSANTS AND ANTIEPILEPTICS

公开(公告)号：US3760804A

公开(公告)日：1973-09-25

申请号：US3760804D

申请日：1971-01-13

Applicant: ALZA CORP

Inventor： HIGUCHI T ,  LEEPER H

IPC: A61F6/14 ,  A61K9/00 ,  A61M31/00

CPC classification number: A61K9/0004 ,  A61F6/14

Abstract: An osmotic dispenser is described which is capable of releasing to its outside environment concentrations of active agent at an osmotically controlled rate over a prolonged period of time, and the motive force of which dispenser depends on the osmotic pressure developed by either (1) an aqueous solution of magnesium sulphate, preferably a saturated aqueous solution, or (2) a saturated aqueous solution of magnesium chloride containing excess magnesium sulphate solute in solid form, against a hypotonic aqueous environment.

Abstract translation: 描述了一种渗透分配器，其能够在更长的时间内以渗透控制的速率释放到其外部环境的活性剂浓度，并且其分配器的动力取决于由（1）水溶液产生的渗透压 硫酸镁溶液，优选饱和水溶液，或（2）含有固体形式的过量的硫酸镁溶质的饱和氯化镁水溶液。