公开(公告)号：US3663552A

公开(公告)日：1972-05-16

申请号：US3663552D

申请日：1970-04-09

Applicant: AMERICAN HOME PROD

Inventor： YARDLEY JOHN P ,  BRIGHT ROYAL E ,  REES RICHARD W ,  SMITH HERCHEL

IPC: C07D453/04 ,  C07D43/24

CPC classification number: C07D453/04 ,  Y10S514/821 ,  Y10S514/895

Abstract: 2''-SUBSTITUTED ALKALOIDS OF THE CINCHONA SERIES, ESPECIALLY 2''-SUBSTITUTED QUININE, QUINIDINE, CINCHONIE, CINCHONIDINE AND DIHYDRO ANALOGS OF FORMULAS I AND II, AND THEIR SALTS, ARE PREPARED BY TREATING AR-N-OXIDES OF THE ALKALOIDS WITH THE CORRESPONDING ORGANOMETALLIC REAGENT AND, IF DESIRED, CONVERTING THE FREE BASES THUS FORMED INTO PHARMACEUTICALLY-ACCEPTABLE ACID-ADDITION SALTS. THE NEW COMPOUNDS ARE PHARMACOLOGICALLY ACTIVE, ESPECIALLY ANTIMALARIALLY AND ANTI-ARRHYTHMICALLY.

公开(公告)号：US3661992A

公开(公告)日：1972-05-09

申请号：US3661992D

申请日：1970-06-29

Applicant: AMERICAN HOME PROD

Inventor： BRIGHT ROYAL E ,  REES RICHARD W ,  SMITH HERCHEL

IPC: C07C87/28 ,  C07C87/66 ,  C07C129/08

CPC classification number: C07C217/62

Abstract: COMPOUNDS OF THE FORMULA 1,1,4,4-(H3C-)4,2-(R1-(R2-)N-)-1,2,3,4-TETRAHYDRONAPHTHALENE WHEREIN R1 IS HYDROGEN OR METHYL; AND R2 IS LOWER ALKYL, LOWER ALKENYL, PHENYL (LOWER) ALKYL, N-AMIDINOAMIDINO, OR 2-GUANIDINO ETHYL ARE PREPARED FROM 1,2,3,4-TETRAHYDRO1,1,4,4-TETRAMETHYL-2-AMINONAPHTHYL AMINE. THE FINAL COMPOUNDS EXERT MYDRIATIC ACTIVITY.

公开(公告)号：US3513160A

公开(公告)日：1970-05-19

申请号：US3513160D

申请日：1968-02-01

Applicant: AMERICAN HOME PROD

Inventor： BRIGHT ROYAL E ,  REES RICHARD W ,  SMITH HERCHEL

IPC: C07J71/00 ,  C07C173/00

CPC classification number: C07J71/00