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1.发明授权Hydroxylation of d-13-alkyl-17{60 -ethynyl-hydroxygon-4-en-3-one and derivatures thereof 失效d-13-烷基-17 {60-乙炔基 - 羟基-4-烯-3-酮及其衍生物的羟基化
公开(公告)号：US3880895A
公开(公告)日：1975-04-29
申请号：US40701573
申请日：1973-10-16
Applicant: AMERICAN HOME PROD
Inventor： GREENSPAN GEORGE , REES RICHARD W
IPC: C07J1/00 , C12P33/00 , C07C169/20
CPC classification number: C07J1/0096 , C12P33/00 , Y10S435/911
Abstract: Incubation of d-13-methyl or ethyl-17 Alpha -ethynyl-17hydroxygon-4-en-3-ones with the fungus Botryodiplodia malorum produces the corresponding 1 Beta -hydroxy derivatives which have anti-estrogenic activity. The 13-methyl- Beta -hydroxy product is formed in admixture with the corresponding 11 Beta -hydroxy compound.
Abstract translation: d-13-甲基或乙基-17α-乙炔基-17-羟基-4-烯-3-酮与真菌Botryodiplodia malorum的孵育产生相应的具有抗雌激素活性的1β-羟基衍生物。 13-甲基-β-羟基产物与相应的11β-羟基化合物混合形成。
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2.发明授权13 - alkyl - 9 - chloromethylgon - 4-en-17beta-ol-3-ones and intermediates therefor 失效13 - ALKYL - 9 - CHLOROMETHYLGON - 4-EN-17BETA-OL-3-ONES及其中间件
公开(公告)号：US3475469A
公开(公告)日：1969-10-28
申请号：US3475469D
申请日：1967-06-27
Applicant: AMERICAN HOME PROD
Inventor： REES RICHARD W , SMITH HERCHEL
IPC: C07J1/00 , C07J75/00 , C07C169/10 , A61K17/00 , C07C169/06
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公开(公告)号：US3661992A
公开(公告)日：1972-05-09
申请号：US3661992D
申请日：1970-06-29
Applicant: AMERICAN HOME PROD
Inventor： BRIGHT ROYAL E , REES RICHARD W , SMITH HERCHEL
IPC: C07C87/28 , C07C87/66 , C07C129/08
CPC classification number: C07C217/62
Abstract: COMPOUNDS OF THE FORMULA 1,1,4,4-(H3C-)4,2-(R1-(R2-)N-)-1,2,3,4-TETRAHYDRONAPHTHALENE WHEREIN R1 IS HYDROGEN OR METHYL; AND R2 IS LOWER ALKYL, LOWER ALKENYL, PHENYL (LOWER) ALKYL, N-AMIDINOAMIDINO, OR 2-GUANIDINO ETHYL ARE PREPARED FROM 1,2,3,4-TETRAHYDRO1,1,4,4-TETRAMETHYL-2-AMINONAPHTHYL AMINE. THE FINAL COMPOUNDS EXERT MYDRIATIC ACTIVITY.
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4.发明授权Process for the preparation of 9alpha-bromo-11beta - hydroxy - 17alpha,20;20,21-bisalkylenedioxy pregnanes 失效制备9ALPHA-BROMO-11BETA-羟基-17ALPHA，20; 20,21-双烯丙基孕酮的方法
公开(公告)号：US3513160A
公开(公告)日：1970-05-19
申请号：US3513160D
申请日：1968-02-01
Applicant: AMERICAN HOME PROD
Inventor： BRIGHT ROYAL E , REES RICHARD W , SMITH HERCHEL
IPC: C07J71/00 , C07C173/00
CPC classification number: C07J71/00
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5.发明授权Process for the preparation of steroidal 1,4-dienes unsubstituted in the 3-position 失效制备在三位置不排除的甾体1,4-二烯的方法
公开(公告)号：US3479340A
公开(公告)日：1969-11-18
申请号：US3479340D
申请日：1967-08-01
Applicant: AMERICAN HOME PROD
Inventor： REES RICHARD W , FOELL THEODORE J , SMITH HERCHEL
IPC: C07J1/00 , C07J5/00 , C07J75/00 , C07C167/00 , A61K27/00 , C07C173/00
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Patent Agency Ranking6.发明授权
公开(公告)号：US3412112A
公开(公告)日：1968-11-19
申请号：US58603066
申请日：1966-10-12
Applicant: AMERICAN HOME PROD
Inventor： FOELL THEODORE J , REES RICHARD W , HERSCHEL SMITH
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7.发明授权6-(fluoro and trifluoromethyl phenyl)-3 5-diamino - 1 2 4 - triazines and substituted - 6 - phenylalkyl-3,5-diamino-1 2 4-triazines 失效6-（氟和三氟甲基苯基）-3 5-二氨基 - 1 2 4 - 三嗪和取代的6-苯基 - 3,5-二氨基-1 2 4-三苯乙烯
公开(公告)号：US3637688A
公开(公告)日：1972-01-25
申请号：US3637688D
申请日：1970-01-09
Applicant: AMERICAN HOME PROD
Inventor： REES RICHARD W , RUSSELL PETER B
IPC: C07C281/18 , C07D253/06 , C07D253/075 , C07D55/10
CPC classification number: C07D253/075 , C07C255/00 , C07C281/18 , Y10S514/895
Abstract: THIS INVENTION INCLUDES BUT IS NOT LIMITED TO COMPOUNDS OF THE FORMULA:
3,5-DI(H2N-),6-(2-R1,3-R2,4-R3,5-R4,6-R5-PHENYL)-
AS-TRIAZINE
WHEREIN R1 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND FLUORINE; R2 R3 AND R4 ARE SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, FLUORINE AND TRIFLUOROMETHYL; R5 IS HYDROGEN, WITH THE PROVISO THAT AT LEAST ONE MEMBER SELECTED FROM THE GROUP CONSISTING OF R1, R2, R3 AND R4 ARE ALWAYS FLUORINE OR TRIFLUOROMETHYL. THE COMPOUNDS ARE USEFUL IN THE TREATMENT OF MALARIA.-
8.发明授权Method of tranquilizing or anti-depressant treatment with alkaloid derivatives 失效用碱性衍生物进行转运或抗抑郁治疗的方法
公开(公告)号：US3531570A
公开(公告)日：1970-09-29
申请号：US3531570D
申请日：1967-04-03
Applicant: AMERICAN HOME PROD
Inventor： REES RICHARD W , SMITH HERCHEL
IPC: A61K31/475 , A61K27/00
CPC classification number: A61K31/475
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公开(公告)号：US3488258A
公开(公告)日：1970-01-06
申请号：US3488258D
申请日：1966-10-07
Applicant: AMERICAN HOME PROD
Inventor： GREENSPAN GEORGE , SMITH LELAND L , REES RICHARD W
CPC classification number: C12P33/00 , C12P33/02 , Y10S435/843
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10.发明授权
公开(公告)号：US3458503A
公开(公告)日：1969-07-29
申请号：US3458503D
申请日：1967-03-30
Applicant: AMERICAN HOME PROD
Inventor： REES RICHARD W , SMITH HERCHEL
IPC: C07J1/00 , C07J75/00 , C07C173/00 , C07C169/12
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