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1.发明授权P-Glu-D-Phe-Trp-Ser-Tyr-D-Phee-Leu-Arg-Pro-Gly-NH2 and intermediates 失效P-Glu-D-Phe-Trp-Ser-Tyr-D-Phee-Leu-Arg-Pro-Gly-NH2和中间体
公开(公告)号：US3928307A
公开(公告)日：1975-12-23
申请号：US52038274
申请日：1974-11-04
Applicant: AMERICAN HOME PROD
Inventor： FOELL THEODORE J , YARDLEY JOHN P
IPC: A61K38/00 , C07K7/23 , C07C103/52 , A61K37/00
CPC classification number: C07K7/23 , A61K38/00 , Y10S514/80 , Y10S930/13 , Y10S930/28
Abstract: D-Phe2-D-Phe6-LRF, is described as well as its synthesis by solid phase techniques and novel intermediates formed by such synthesis. The novel decapeptide exhibits anti-ovulatory activity in mammals.
Abstract translation: 描述了D-Phe2-D-Phe6-LRF，以及其通过固相技术的合成和通过这种合成形成的新型中间体。 新癸酰胺在哺乳动物中表现出抗排卵活性。
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公开(公告)号：US3637744A
公开(公告)日：1972-01-25
申请号：US3637744D
申请日：1969-04-04
Applicant: AMERICAN HOME PROD
Inventor： YARDLEY JOHN P , SMITH HERCHEL
IPC: C07D487/04 , C07D27/54
CPC classification number: C07D487/04
Abstract: THIS INVENTION IS CONCERNED WITH 2,3,4,5,6,7-HEXAHYDRO1H-INDOLO(5,4-B)AZOCINES, DERIVATIVES THEREOF AND THEIR ACID ADDITION SALTS WHICH ARE USEFUL AS CENTRAL SYSTEM DEPRESSANTS. FURTHER, SOME OF THESE COMPOUNDS ARE USEFUL INTERMIEDIATES IN THE PREPARATION OF OTHER SUCH COMPOUNDS.
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公开(公告)号：US3928626A
公开(公告)日：1975-12-23
申请号：US34503773
申请日：1973-03-26
Applicant: AMERICAN HOME PROD
Inventor： YARDLEY JOHN P , RUSSELL PETER B
IPC: A61K31/135 , A61K31/40 , A61K31/535
CPC classification number: A61K31/135
Abstract: Reaction of benzalcyclanones with secondary amines affords aminobenzylcyclohexanones, which, upon reduction, yield aminobenzylcyclohexanols having potent analgesic activity. Epimeric aminobenzylcycloalkanols having analgesic activity are prepared by the reaction of C-phenyl nitrones with cycloalkenes to form benzisoxazoles, treatment with alkyl halide to form the corresponding benzisoxazolium halides, followed by hydrogenolysis.
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Patent Agency Ranking4.发明授权P-Glu-D-p-F-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH{HD 2 失效P-Glu-D-p-F-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH {HD 2
公开(公告)号：US3928308A
公开(公告)日：1975-12-23
申请号：US52038374
申请日：1974-11-04
Applicant: AMERICAN HOME PROD
Inventor： YARDLEY JOHN P
IPC: A61K38/00 , C07K7/23 , C07C103/52 , A61K37/00
CPC classification number: C07K7/23 , A61K38/00 , Y10S514/80 , Y10S930/13 , Y10S930/28
Abstract: D-p-F-Phe2-D-Ala6-LRF, is described as well as its synthesis by solid phase techniques and novel intermediates formed by such synthesis. The novel decapeptide exhibits anti-ovulatory activity in mammals.
Abstract translation: 描述了D-p-F-Phe2-D-Ala6-LRF，以及其通过固相技术的合成和通过这种合成形成的新型中间体。 新癸酰胺在哺乳动物中表现出抗排卵活性。
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5.发明授权(n-propionyl) -gly-cys-lys-asn-phe-phe-trp-lys-thr-phe-thr-ser-cys-oh and intermediates 失效（N-丙酸）-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH和中间体
公开(公告)号：US3896105A
公开(公告)日：1975-07-22
申请号：US45715874
申请日：1974-04-01
Applicant: AMERICAN HOME PROD
Inventor： CHAI SIE-YEARL , YARDLEY JOHN P
IPC: A61K38/00 , C07K14/655 , C07C103/52 , A61K37/00
CPC classification number: C07K14/655 , A61K38/00 , Y10S514/806 , Y10S530/815 , Y10S930/16 , Y10S930/28
Abstract: The tridecapeptide (N-propionyl)-Gly-Cys-Lys-Asn-Phe-Phe-TrpLys-Thr-Phe-Thr-Ser-Cys-OH, its oxidized form as well as novel intermediates used in the synthesis of such tridecapeptides are described. These tridecapeptides inhibit the secretion of the hormone somatotropin (growth hormone).
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公开(公告)号：US3663552A
公开(公告)日：1972-05-16
申请号：US3663552D
申请日：1970-04-09
Applicant: AMERICAN HOME PROD
Inventor： YARDLEY JOHN P , BRIGHT ROYAL E , REES RICHARD W , SMITH HERCHEL
IPC: C07D453/04 , C07D43/24
CPC classification number: C07D453/04 , Y10S514/821 , Y10S514/895
Abstract: 2''-SUBSTITUTED ALKALOIDS OF THE CINCHONA SERIES, ESPECIALLY 2''-SUBSTITUTED QUININE, QUINIDINE, CINCHONIE, CINCHONIDINE AND DIHYDRO ANALOGS OF FORMULAS I AND II, AND THEIR SALTS, ARE PREPARED BY TREATING AR-N-OXIDES OF THE ALKALOIDS WITH THE CORRESPONDING ORGANOMETALLIC REAGENT AND, IF DESIRED, CONVERTING THE FREE BASES THUS FORMED INTO PHARMACEUTICALLY-ACCEPTABLE ACID-ADDITION SALTS. THE NEW COMPOUNDS ARE PHARMACOLOGICALLY ACTIVE, ESPECIALLY ANTIMALARIALLY AND ANTI-ARRHYTHMICALLY.
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7.发明授权Method of inhibiting fertility in mammals using D{13 Phe{hu 2{b {13 D{13 Ala{hu 6{b {13 LRF 失效使用D {13 Phe {hu 2 {b {13 D {13 Ala {hu 6 {b {13 LRF））来抑制哺乳动物的生殖力的方法
公开(公告)号：US3890437A
公开(公告)日：1975-06-17
申请号：US48612474
申请日：1974-07-05
Applicant: AMERICAN HOME PROD
Inventor： FOELL THEODORE J , YARDLEY JOHN P
IPC: A61K38/00 , C07K7/23 , A61K27/00 , C07C103/52
CPC classification number: C07K7/23 , A61K38/00 , Y10S514/80 , Y10S930/13
Abstract: D-Phe2-D-Ala6-LRF, is described as well as its synthesis by solid phase techniques and novel intermediates formed by such synthesis. The novel decapeptide exhibits anti-ovulatory activity in mammals.
Abstract translation: 描述了D-Phe2-D-Ala6-LRF，以及其通过固相技术的合成和通过这种合成形成的新型中间体。 新癸酰胺在哺乳动物中表现出抗排卵活性。
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8.发明授权P-Glu-D-Phe-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-Gly-NH{HD 2 {B and intermediates 失效P-Glu-D-Phe-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-Gly-NH {HD 2 {B和中间体
公开(公告)号：US3886137A
公开(公告)日：1975-05-27
申请号：US41798373
申请日：1973-11-21
Applicant: AMERICAN HOME PROD
Inventor： YARDLEY JOHN P
IPC: A61K38/00 , C07K7/23 , C07C103/52 , A61K27/00 , C07G7/00
CPC classification number: C07K7/23 , A61K38/00 , Y10S514/80 , Y10S930/13 , Y10S930/28
Abstract: D-Phe2-D-Leu6-LRF, is described as well as its synthesis by solid phase techniques and novel intermediates formed by such synthesis. The novel decapeptide exhibits anti-ovulatory activity in mammals.
Abstract translation: 描述了D-Phe2-D-Leu6-LRF，以及其通过固相技术的合成和通过这种合成形成的新型中间体。 新癸酰胺在哺乳动物中表现出抗排卵活性。
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