公开(公告)号：US20150087819A1

公开(公告)日：2015-03-26

申请号：US14562546

申请日：2014-12-05

Applicant: AMGEN INC.

Inventor： SIMON MARK JACKSON ,  NIGEL PELHAM CLINTON WALKER ,  DEREK EVAN PIPER ,  BEI SHAN ,  WENYAN SHEN ,  JOYCE CHI YEE CHAN ,  CHADWICK TERENCE KING ,  RANDAL ROBERT KETCHEM ,  CHRISTOPHER MEHLIN ,  TERESA ARAZAS CARABEO ,  QIONG CAO

IPC: C07K16/40

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

公开(公告)号：US20130144041A1

公开(公告)日：2013-06-06

申请号：US13678376

申请日：2012-11-15

Applicant: AMGEN INC.

Inventor： THOMAS M. DILLON ,  PAVEL BONDARENKO ,  JETTE WYPYCH ,  MARTIN J. ALLEN ,  ALAIN BALLAND ,  MARGARET SPEED RICCI ,  AMY GUO ,  WENYAN SHEN ,  JEONGHOON SUN ,  CHRIS VEZINA

IPC: C07K16/24

CPC classification number: C07K16/245 ,  C07K16/00 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/2875 ,  C07K2317/53 ,  C07K2317/56

Abstract: The present invention is generally directed to methods of producing an increase in the enrichment and/or recovery of preferred forms of monoclonal antibodies. More particularly, the invention relates to methods for eliminating disulfide heterogeneity in the hinge region of recombinant IgG2 antibody proteins.

Abstract translation: 本发明一般涉及产生增殖和/或回收优选形式的单克隆抗体的方法。 更具体地说，本发明涉及消除重组IgG2抗体蛋白的铰链区中二硫键异质性的方法。

公开(公告)号：US20130079502A1

公开(公告)日：2013-03-28

申请号：US13682698

申请日：2012-11-20

Applicant: AMGEN, INC.

Inventor： SIMON MARK JACKSON ,  BEI SHAN ,  WENYAN SHEN ,  JOYCE CHI YEE CHAN ,  CHADWICK TERENCE KING

IPC: C07K16/40

CPC classification number: C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  A61K2300/00

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.