公开(公告)号：US20230357137A1

公开(公告)日：2023-11-09

申请号：US17923015

申请日：2021-04-28

申请人： AMGEN INC.

发明人： Neil Fred LANGILLE ,  Jason S. TEDROW ,  Jonathan Vinh-Phu TRUONG ,  Robert Ronald MILBURN ,  Alessandro ARENA

IPC分类号： C07C303/36 ,  C07D513/06 ,  C07D519/00 ,  C07C67/08 ,  C07D301/24 ,  C07C29/62 ,  C07C303/28 ,  C07D213/70 ,  C07D213/71

CPC分类号： C07C303/36 ,  C07D513/06 ,  C07D519/00 ,  C07C67/08 ,  C07D301/24 ,  C07C29/62 ,  C07C303/28 ,  C07D213/70 ,  C07D213/71 ,  C07B2200/13

摘要： Provided herein are processes for synthesizing mcl-1 inhibitors and intermediates such as compound Z that can be used to prepare them. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.