公开(公告)号：US20230167130A1

公开(公告)日：2023-06-01

申请号：US17922619

申请日：2021-05-05

申请人： AMGEN INC.

发明人： Austin G. SMITH ,  Jason S. TEDROW ,  Gabrielle ST-PIERRE ,  Oliver Ralf THIEL ,  Liang HUANG ,  Philipp C. ROOSEN ,  John T. COLYER ,  Kyle D. BAUCOM ,  Ari ERICSON ,  Matthew G. BEAVER ,  Rahul P. SANGODKAR ,  Michael A. LOVETTE ,  Robert Ronald MILBURN ,  Alan H. CHERNEY ,  Sheng CUI

IPC分类号： C07D513/10 ,  C07D267/16

CPC分类号： C07D513/10 ,  C07D267/16

摘要： Provided herein are processes for synthesizing Mcl-1 inhibitors and intermediates such as compound F that can be used to prepare them where the variable PG is as defined herein. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.

公开(公告)号：US20230357137A1

公开(公告)日：2023-11-09

申请号：US17923015

申请日：2021-04-28

申请人： AMGEN INC.

发明人： Neil Fred LANGILLE ,  Jason S. TEDROW ,  Jonathan Vinh-Phu TRUONG ,  Robert Ronald MILBURN ,  Alessandro ARENA

IPC分类号： C07C303/36 ,  C07D513/06 ,  C07D519/00 ,  C07C67/08 ,  C07D301/24 ,  C07C29/62 ,  C07C303/28 ,  C07D213/70 ,  C07D213/71

CPC分类号： C07C303/36 ,  C07D513/06 ,  C07D519/00 ,  C07C67/08 ,  C07D301/24 ,  C07C29/62 ,  C07C303/28 ,  C07D213/70 ,  C07D213/71 ,  C07B2200/13

摘要： Provided herein are processes for synthesizing mcl-1 inhibitors and intermediates such as compound Z that can be used to prepare them. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.