公开(公告)号：US10597456B2

公开(公告)日：2020-03-24

申请号：US15476699

申请日：2017-03-31

Applicant: KITE PHARMA, Inc. ,  AMGEN INC.

Inventor： Jed Wiltzius ,  Ruben Alvarez Rodriguez ,  Alice Bakker ,  Lawren Wu ,  Tara Arvedson

IPC: C07K16/28 ,  C07K14/725 ,  C07K14/705 ,  A61K39/00 ,  C07K14/435 ,  C12N15/86

Abstract: Antigen binding molecules, chimeric receptors, and engineered immune cells are disclosed in accordance with the invention. The invention further relates to vectors, compositions, and methods of treatment and/or detection using the antigen binding molecules and engineered immune cells.

公开(公告)号：US09708375B2

公开(公告)日：2017-07-18

申请号：US14776917

申请日：2014-03-14

Applicant: AMGEN INC.

Inventor： Ryan B. Case ,  Benjamin M. Alba ,  Alice Bakker ,  Irwin Chen ,  Amy N. Duguay ,  Monica Florio ,  Peng Li ,  Mark Leo Michaels ,  Mei-Mei Tsai

IPC: C07K14/435 ,  C07K16/18 ,  C07K14/51 ,  A61K47/48

CPC classification number: C07K14/435 ,  A61K47/60 ,  C07K14/51 ,  C07K16/18 ,  C07K2319/31

Abstract: The present application is directed to avimers and peptides and various combinations thereof in addition to methods of making and using them.

公开(公告)号：US20130197191A1

公开(公告)日：2013-08-01

申请号：US13738900

申请日：2013-01-10

Applicant: AMGEN INC.

Inventor： Richard Smith ,  Alice Bakker ,  Amy N Duguay ,  Peng Li ,  Yang Li

IPC: C07K14/00

CPC classification number: C07K14/001 ,  A61K38/00 ,  C07K14/50 ,  C07K14/705 ,  C07K2319/70 ,  C07K2319/75

Abstract: Binding proteins that specifically bind to β-Klotho or portions thereof, FGFR1c or portions thereof, or both FGFR1c and β-Klotho, and optionally other proteins as well are provided. Coding sequences, methods of treatment and pharmaceutical compositions are also provided.

Abstract translation: 提供了与β-Klotho或其部分特异性结合的结合蛋白，FGFR1c或其部分，或FGFR1c和β-Klotho以及任选的其它蛋白质。 还提供编码序列，治疗方法和药物组合物。