公开(公告)号：US12012462B2

公开(公告)日：2024-06-18

申请号：US17046731

申请日：2019-04-10

Applicant: AMGEN INC. ,  KiTe Pharma, Inc.

Inventor： Michael John Giffin ,  Melissa Thomas ,  Christopher Murawsky ,  Ryan B. Case ,  Lawren Wu ,  Jed J. Wiltzius ,  Ruben Alvarez Rodriguez ,  Jun Feng

IPC: C07K16/30 ,  A61K39/00 ,  A61P35/00 ,  C07K14/705 ,  C12N15/86

CPC classification number: C07K16/30 ,  A61P35/00 ,  C07K14/70517 ,  C07K14/70521 ,  C12N15/86 ,  A61K2039/505 ,  C07K2317/565 ,  C07K2317/622 ,  C12N2740/15041

Abstract: Antigen binding molecules, chimeric receptors, and engineered immune cells to DLL3 are disclosed in accordance with the invention. The invention further relates to vectors, compositions, and methods of treatment and/or detection using the DLL3 antigen binding molecules and engineered immune cells.

公开(公告)号：US09708375B2

公开(公告)日：2017-07-18

申请号：US14776917

申请日：2014-03-14

Applicant: AMGEN INC.

Inventor： Ryan B. Case ,  Benjamin M. Alba ,  Alice Bakker ,  Irwin Chen ,  Amy N. Duguay ,  Monica Florio ,  Peng Li ,  Mark Leo Michaels ,  Mei-Mei Tsai

IPC: C07K14/435 ,  C07K16/18 ,  C07K14/51 ,  A61K47/48

CPC classification number: C07K14/435 ,  A61K47/60 ,  C07K14/51 ,  C07K16/18 ,  C07K2319/31

Abstract: The present application is directed to avimers and peptides and various combinations thereof in addition to methods of making and using them.