公开(公告)号：US11071826B2

公开(公告)日：2021-07-27

申请号：US16188445

申请日：2018-11-13

Applicant: AMGEN INC.

Inventor： Andrew Coles ,  Chad Quistad ,  Emanuele Strada ,  Francesco Lauritano ,  Alessia Mazzicone ,  Antonio Antonini

IPC: A61M5/24 ,  A61M5/32 ,  A61M5/315 ,  A61M5/20

Abstract: A drug delivery device includes a housing defining a shell and an inner volume, a cassette, a door coupled to the housing, a drive mechanism, and a latching assembly. The cassette is removably disposed within the inner volume and is adapted to contain a drug to be administered to a user. The door at least partially encloses the inner volume of the housing and includes a first end defining a latching portion. The drive mechanism is at least partially disposed within the housing and exerts a force to urge the drug out the cassette. The latching assembly is coupled to the drive mechanism and includes a first end and a second end. Upon actuating the drive mechanism, the drive mechanism causes the latching assembly to engage the latching portion of the door to secure the door to the housing.

公开(公告)号：US20220347398A1

公开(公告)日：2022-11-03

申请号：US17621135

申请日：2020-06-16

Applicant: AMGEN INC.

Inventor： Sivakumar Paramanandam ,  Andrew Coles ,  Keng-Tong See ,  Desheng Yin

IPC: A61M5/50

Abstract: This disclosure describes a drug delivery device with communication functionality for purposes of transferring information to a user device, such as a smartphone, while maintaining power-efficient operation. The drug delivery device comprises a controller configured to, while operating in the active mode, use one or more sensors to detect that the injection mechanism has performed an injection. The controller is also configured to generate in memory a data entry indicative of the injection and/or a state of the drug delivery device, and switch into the low-power mode subsequent to or contemporaneous with detecting that the injection mechanism has performed the injection. The drug delivery device also comprises a wireless communication module powered by the power source and configured to establish a wireless connection with and transfer a message to a user device while the controller is operating in the low-power mode.

公开(公告)号：US20220257864A1

公开(公告)日：2022-08-18

申请号：US17537922

申请日：2021-11-30

Applicant: AMGEN INC.

Inventor： Sivakumar Paramanandam ,  Andrew Coles ,  Nicola Antonio Alagia ,  Antonio Antonini

IPC: A61M5/24 ,  A61M5/31 ,  A61M5/315 ,  A61M5/145 ,  A61M5/20

Abstract: An autoinjector drug delivery device configured with a stall and endpoint detection algorithm is described that allows for variations in the fill of the drug, barrel, plunger, and other components. The stall or end point detection can cause the autoinjector to stop an extrusion process.

公开(公告)号：US20240082507A1

公开(公告)日：2024-03-14

申请号：US17767462

申请日：2020-10-07

Applicant: AMGEN INC.

Inventor： Samin Akbari ,  Azita Rahbari ,  Sunitha Dasoju ,  Andrew Coles ,  Jerome Olivas ,  Michele Macchi ,  Desheng Yin ,  Harpreet Sachar ,  Alireza Ashani ,  Angelo Tosarini ,  Antonio Antonini

IPC: A61M5/32

CPC classification number: A61M5/3257 ,  A61M5/3213

Abstract: A cassette for a drug delivery device is described that includes a sleeve, a syringe having a barrel disposed in the sleeve, and a plunger-stopper slidably disposed within the barrel. The cassette further includes a spacer that is configured to be coupled to the sleeve. The cassette can form a part of an apparatus for injection of a therapeutic product along with a drug delivery device.

公开(公告)号：US20190143043A1

公开(公告)日：2019-05-16

申请号：US16188445

申请日：2018-11-13

Applicant: AMGEN INC.

Inventor： Andrew Coles ,  Chad Quistad ,  Emanuele Strada ,  Francesco Lauritano ,  Alessia Mazzicone ,  Antonio Antonini

IPC: A61M5/24 ,  A61M5/32 ,  A61M5/315

Abstract: A drug delivery device includes a housing defining a shell and an inner volume, a cassette, a door coupled to the housing, a drive mechanism, and a latching assembly. The cassette is removably disposed within the inner volume and is adapted to contain a drug to be administered to a user. The door at least partially encloses the inner volume of the housing and includes a first end defining a latching portion. The drive mechanism is at least partially disposed within the housing and exerts a force to urge the drug out the cassette. The latching assembly is coupled to the drive mechanism and includes a first end and a second end. Upon actuating the drive mechanism, the drive mechanism causes the latching assembly to engage the latching portion of the door to secure the door to the housing.

公开(公告)号：US20220184318A1

公开(公告)日：2022-06-16

申请号：US17437615

申请日：2020-04-10

Applicant: AMGEN INC.

Inventor： Azita Rahbari ,  Sunitha Dasoju ,  Angelo Tosarini ,  Antonio Antonini ,  Julian Jazayeri ,  Harpreet Sachar ,  Andrew Coles ,  Desheng Yin ,  Alireza Ashani

IPC: A61M5/315 ,  A61M5/32 ,  A61M5/24

Abstract: A cassette for a drug delivery device is described that includes a sleeve, a syringe having a barrel disposed in the sleeve, and a plunger-stopper slidably disposed within the barrel. An end cap is adapted to couple to the sleeve to secure the syringe in the sleeve. The cassette further includes a spacer that is sized to be slidably moved within the barrel and the spacer is disposed distal to the plunger-stopper to be engaged by a plunger rod to slide within the barrel and engage the plunger-stopper. In some forms, the spacer can be coupled to the end cap.

公开(公告)号：US11213626B2

公开(公告)日：2022-01-04

申请号：US16188496

申请日：2018-11-13

Applicant: AMGEN INC.

Inventor： Sivakumar Paramanandam ,  Andrew Coles ,  Nicola Alagia ,  Antonio Antonini

IPC: A61M5/24 ,  A61M5/31 ,  A61M5/315 ,  A61M5/145 ,  A61M5/20 ,  A61M5/32

Abstract: An autoinjector drug delivery device configured with a stall and endpoint detection algorithm is described that allows for variations in the fill of the drug, barrel, plunger, and other components. The stall or end point detection causes the autoinjector to stop an extrusion process.

公开(公告)号：US20190143044A1

公开(公告)日：2019-05-16

申请号：US16188496

申请日：2018-11-13

Applicant: AMGEN INC.

Inventor： Sivakumar Paramanandam ,  Andrew Coles ,  Nicola Alagia ,  Antonio Antonini

IPC: A61M5/24 ,  A61M5/31 ,  A61M5/315

Abstract: An autoinjector drug delivery device configured with a stall and endpoint detection algorithm is described that allows for variations in the fill of the drug, barrel, plunger, and other components. The stall or end point detection causes the autoinjector to stop an extrusion process.