公开(公告)号：US20240245686A1

公开(公告)日：2024-07-25

申请号：US18545932

申请日：2023-12-19

Applicant: Amgen Inc.

Inventor： James Russell LIPFORD ,  Jude Robert CANON ,  Anne Y. SAIKI ,  Karen Louise REX

IPC: A61K31/519 ,  A61K31/555 ,  A61P35/00 ,  C07K16/28

CPC classification number: A61K31/519 ,  A61P35/00 ,  A61K31/555 ,  C07K16/2818

Abstract: The present invention provides combination therapy that includes an KRASG12C inhibitor, such as




or a pharmaceutically acceptable salt thereof, and one or more additional pharmaceutically active agents, particularly for the treatment of cancers. The invention also relates to pharmaceutical compositions that contain an KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers.

公开(公告)号：US20230121955A1

公开(公告)日：2023-04-20

申请号：US17870573

申请日：2022-07-21

Applicant: Amgen Inc.

Inventor： James Russell LIPFORD ,  Jude Robert CANON ,  Anne Y. SAIKI ,  Karen Louise REX

IPC: A61K31/519 ,  A61P35/00 ,  C07K16/28 ,  A61K31/555

Abstract: The present invention provides combination therapy that includes an KRASG12C inhibitor, such as or a pharmaceutically acceptable salt thereof, and one or more additional pharmaceutically active agents, particularly for the treatment of cancers. The invention also relates to pharmaceutical compositions that contain an KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers.

公开(公告)号：US20240173328A1

公开(公告)日：2024-05-30

申请号：US18545953

申请日：2023-12-19

Applicant: Amgen Inc.

Inventor： James Russell LIPFORD ,  Jude Robert CANON ,  Anne Y. SAIKI ,  Karen Louise REX

IPC: A61K31/519 ,  A61P35/00

CPC classification number: A61K31/519 ,  A61P35/00 ,  A61K31/555

Abstract: The present invention provides combination therapy that includes an KRASG12C inhibitor, such as




or a pharmaceutically acceptable salt thereof, and one or more additional pharmaceutically active agents, particularly for the treatment of cancers. The invention also relates to pharmaceutical compositions that contain an KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers.

公开(公告)号：US20200222407A1

公开(公告)日：2020-07-16

申请号：US16687563

申请日：2019-11-18

Applicant: Amgen Inc.

Inventor： James Russell LIPFORD ,  Jude Robert CANON ,  Anne Y. SAIKI ,  Karen Louise REX

IPC: A61K31/519 ,  A61P35/00

Abstract: The present invention provides combination therapy that includes an KRASG12C inhibitor, such as or a pharmaceutically acceptable salt thereof, and one or more additional pharmaceutically active agents, particularly for the treatment of cancers. The invention also relates to pharmaceutical compositions that contain an KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers.

公开(公告)号：US20160287569A1

公开(公告)日：2016-10-06

申请号：US15035438

申请日：2014-11-11

Applicant: AMGEN INC.

Inventor： Sean CAENEPEEL ,  Jude CANON ,  Paul HUGHES ,  Jonathan D. OLINER ,  Anne Y. SAIKI ,  Richard J. RICKLES

IPC: A61K31/451 ,  A61K31/437 ,  A61K31/519 ,  A61K31/5025 ,  A61K31/496 ,  A61K31/365 ,  A61K31/166 ,  A61K31/635 ,  A61K31/4045 ,  A61K31/706 ,  A61K31/7068 ,  A61K31/704 ,  A61K31/506 ,  A61K31/44

CPC classification number: A61K31/451 ,  A61K31/166 ,  A61K31/365 ,  A61K31/4045 ,  A61K31/437 ,  A61K31/44 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/519 ,  A61K31/635 ,  A61K31/704 ,  A61K31/706 ,  A61K31/7068 ,  A61K2300/00

Abstract: The present invention provides combination therapy that includes an MDM2 inhibitor and one or more additional pharmaceutically active agents, particularly for the treatment of cancers. The invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers.

Abstract translation: 本发明提供了包括MDM2抑制剂和一种或多种另外的药物活性剂，特别是用于治疗癌症的组合疗法。 本发明还涉及含有MDM2抑制剂和一种或多种用于治疗癌症的另外的药物活性剂的药物组合物。