公开(公告)号：US20170182016A1

公开(公告)日：2017-06-29

申请号：US15300690

申请日：2015-04-03

Applicant: AMGEN, INC.

Inventor： Sean CAENEPEEL ,  Angela COXON ,  Zhiqiang DU ,  Paul HUGHES ,  Robert LOBERG ,  Gift NGARMCHAMNANRITH ,  Beate SABLE

IPC: A61K31/4375 ,  C12Q1/68

CPC classification number: A61K31/4375 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/154 ,  C12Q2600/158

Abstract: The present invention relates to methods of therapeutic treatment of cancer using selective tyrosine kinase inhibitors and cancer biomarkers, such as MET amplification and high Met expression for patient selection.

公开(公告)号：US20160287569A1

公开(公告)日：2016-10-06

申请号：US15035438

申请日：2014-11-11

Applicant: AMGEN INC.

Inventor： Sean CAENEPEEL ,  Jude CANON ,  Paul HUGHES ,  Jonathan D. OLINER ,  Anne Y. SAIKI ,  Richard J. RICKLES

IPC: A61K31/451 ,  A61K31/437 ,  A61K31/519 ,  A61K31/5025 ,  A61K31/496 ,  A61K31/365 ,  A61K31/166 ,  A61K31/635 ,  A61K31/4045 ,  A61K31/706 ,  A61K31/7068 ,  A61K31/704 ,  A61K31/506 ,  A61K31/44

CPC classification number: A61K31/451 ,  A61K31/166 ,  A61K31/365 ,  A61K31/4045 ,  A61K31/437 ,  A61K31/44 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/519 ,  A61K31/635 ,  A61K31/704 ,  A61K31/706 ,  A61K31/7068 ,  A61K2300/00

Abstract: The present invention provides combination therapy that includes an MDM2 inhibitor and one or more additional pharmaceutically active agents, particularly for the treatment of cancers. The invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers.

Abstract translation: 本发明提供了包括MDM2抑制剂和一种或多种另外的药物活性剂，特别是用于治疗癌症的组合疗法。 本发明还涉及含有MDM2抑制剂和一种或多种用于治疗癌症的另外的药物活性剂的药物组合物。