公开(公告)号：US20190127452A1

公开(公告)日：2019-05-02

申请号：US16099986

申请日：2017-05-11

Applicant: AMGEN INC.

Inventor： Randal Robert KETCHEM ,  Jeffrey T. MCGREW ,  Dina A. FOMINA YADLIN ,  Trent P. MUNRO ,  Neeraj Jagdish AGRAWAL ,  Kristine M. DARIS

IPC: C07K16/18 ,  C12N15/67 ,  C12N15/65 ,  C12N15/85 ,  C07K16/06

Abstract: This invention relates to the general field of recombinant expression of polypeptides in animal cell culture. More specifically, the invention concerns improved selection of cells transfected with recombinantly engineered vectors designed to express polypeptides, in particular heteromultimeric polypeptides.