公开(公告)号：US20240174752A1

公开(公告)日：2024-05-30

申请号：US18284590

申请日：2022-04-26

Applicant: AMGEN INC.

Inventor： Li ZHANG ,  Hedieh BARKHORDARIAN ,  Ewelina ZASADZINSKA ,  Jonathan DIEP

IPC: C07K16/28 ,  C07K14/54

CPC classification number: C07K16/2818 ,  C07K14/54 ,  C07K2317/31 ,  C07K2319/30

Abstract: The present invention relates to the field of biopharmaceutical manufacturing. In particular, the invention relates to using temperature as a lever to modulate product quality during upstream operations.