公开(公告)号：US20140378665A1

公开(公告)日：2014-12-25

申请号：US14374885

申请日：2013-01-28

Applicant: AMGEN INC.

Inventor： Yumei Xiong ,  Yi Zhang ,  Jackie Zeqi Sheng ,  Agnes Eva Hamburger ,  Murielle Veniant-Ellison ,  Grant Shimamoto ,  Xiaoshan Min ,  Zhulun Wang ,  Jie Tang ,  Gunasekaran Kannan ,  Kenneth W. Walker ,  Bryan Lemon

IPC: C07K14/475

CPC classification number: C07K14/475 ,  A61K39/0005 ,  A61K2039/6056 ,  C07K2319/30

Abstract: GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

Abstract translation: 提供GDF15多肽，包含GDF15的构建体及其突变体。 在各种实施方案中，GDF15多肽，包含GDF15的构建体及其突变体可用于治疗或改善代谢紊乱。 在各种实施方案中，代谢疾病或病症是2型糖尿病，肥胖症，血脂异常，升高的葡萄糖水平，升高的胰岛素水平和糖尿病性肾病。

公开(公告)号：US09714276B2

公开(公告)日：2017-07-25

申请号：US14374885

申请日：2013-01-28

Applicant: AMGEN INC

Inventor： Yumei Xiong ,  Yi Zhang ,  Jackie Zeqi Sheng ,  Agnes Eva Hamburger ,  Murielle Veniant-Ellison ,  Grant Shimamoto ,  Xiaoshan Min ,  Zhulun Wang ,  Jie Tang ,  Gunasekaran Kannan ,  Kenneth W. Walker ,  Bryan Lemon

IPC: C07K14/00 ,  C07K14/475 ,  A61K39/00 ,  C12N15/62

CPC classification number: C07K14/475 ,  A61K39/0005 ,  A61K2039/6056 ,  C07K2319/30

Abstract: GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.