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公开(公告)号:US20200024319A1
公开(公告)日:2020-01-23
申请号:US15565376
申请日:2016-05-04
申请人: AMGEN INC. , Amgen Inc.
发明人: Eric Alan BUTZ , Christy Ann THOMSON , Marc Alain GAVIN , Ian Nevin FOLTZ , Dong XIA , Dina N. ALCORN , Ai Ching LIM , Randal Robert KETCHUM , Kathy MANCHULENKO , Laura SEKIROV , Kelly Ann BERRY , Cyr Clovis Chua DE IMUS , Neeraj Jagdish AGRAWAL , Gunasekaran KANNAN , Li LI
摘要: Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.
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公开(公告)号:US20240360079A1
公开(公告)日:2024-10-31
申请号:US18291285
申请日:2022-08-17
申请人: AMGEN INC.
发明人: Adrian ORTIZ , Jaika DOERFLER , Karina R. VAIDA
IPC分类号: C07C319/12 , C07C321/26 , C12P13/00
CPC分类号: C07C319/12 , C07C321/26 , C12P13/001
摘要: The present invention relates to precious metal (Pd/Pt/Rh/Ru) free, preferably Pd free, processes for preparing a compound having formula (1) wherein: R1, R2, and X are as defined in the specification, or a salt thereof. Preferably, the compound is an iodo acrylate compound.
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公开(公告)号:USD1049367S1
公开(公告)日:2024-10-29
申请号:US29909619
申请日:2023-08-08
申请人: AMGEN INC.
摘要: FIG. 1 is a perspective view showing a new design for a handheld drug delivery device with its needle shield in an extended position;
FIG. 2 is a front view of the handheld drug delivery device of FIG. 1;
FIG. 3 is a rear view of the handheld drug delivery device of FIG. 1;
FIG. 4 is a right-side view of the handheld drug delivery device of FIG. 1;
FIG. 5 is a left-side view of the handheld drug delivery device of FIG. 1;
FIG. 6 is a top view of the handheld drug delivery device of FIG. 1;
FIG. 7 is a bottom view of the handheld drug delivery device of FIG. 1;
FIG. 8 is a perspective view of the handheld drug delivery device of FIG. 1 with its needle shield in a retracted position;
FIG. 9 is a front view of the handheld drug delivery device of FIG. 8;
FIG. 10 is a rear view of the handheld drug delivery device of FIG. 8;
FIG. 11 is a right-side view of the handheld drug delivery device of FIG. 8;
FIG. 12 is a left-side view of the handheld drug delivery device of FIG. 8;
FIG. 13 is a top view of the handheld drug delivery device of FIG. 8;
FIG. 14 is a bottom view of the handheld drug delivery device of FIG. 8;
FIG. 15 is a perspective view showing a new design for a handheld drug delivery device with its needle shield in an extended position;
FIG. 16 is a front view of the handheld drug delivery device of FIG. 15;
FIG. 17 is a rear view of the handheld drug delivery device of FIG. 15;
FIG. 18 is a right-side view of the handheld drug delivery device of FIG. 15;
FIG. 19 is a left-side view of the handheld drug delivery device of FIG. 15;
FIG. 20 is a top view of the handheld drug delivery device of FIG. 15;
FIG. 21 is a bottom view of the handheld drug delivery device of FIG. 15;
FIG. 22 is a perspective view of the handheld drug delivery device of FIG. 15 with its needle shield in a retracted position;
FIG. 23 is a front view of the handheld drug delivery device of FIG. 22;
FIG. 24 is a rear view of the handheld drug delivery device of FIG. 22;
FIG. 25 is a right-side view of the handheld drug delivery device of FIG. 22;
FIG. 26 is a left-side view of the handheld drug delivery device of FIG. 22;
FIG. 27 is a top view of the handheld drug delivery device of FIG. 22; and,
FIG. 28 is a bottom view of the handheld drug delivery device of FIG. 22.
The broken lines are included for the purpose of illustrating portions of the design that form no part of the claimed design.-
公开(公告)号:US20240352112A1
公开(公告)日:2024-10-24
申请号:US18525130
申请日:2023-11-30
申请人: AMGEN INC.
发明人: Zhe Huang , Jennitte LeAnn Stevens , Greg Flynn , Szilan Fodor , Mark Daris
CPC分类号: C07K16/22 , A61K47/12 , A61K47/26 , A61K2039/505 , C07K2317/24
摘要: The invention generally relates to anti-sclerostin antibodies having C-terminal modifications, and compositions comprising such antibodies.
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公开(公告)号:US20240344920A1
公开(公告)日:2024-10-17
申请号:US18685086
申请日:2022-08-22
申请人: AMGEN INC.
发明人: Al Patrick Goodwin , Joseph Peter Bermacki , Thomas Clark Pearson , Graham F. Milne , Jonathan Parsons , Corey Bishop , Barry Donohoe , Osvaldo Perez-Varela
CPC分类号: G01M3/38 , G01B11/2522 , G01N21/909 , G01N2201/0612
摘要: An apparatus, system, or method for vial seal inspection may be based on three-dimensional data that is representative of at least a portion of a vial seal. More particularly, apparatuses, systems, and methods for vial seal inspection may include at least one laser triangulation sensor.
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公开(公告)号:US20240343832A1
公开(公告)日:2024-10-17
申请号:US18644757
申请日:2024-04-24
申请人: AMGEN INC.
发明人: JOON HOI HUH , RIKI STEVENSON , PAVEL BONDARENKO , ANDREW NICHOLS , DA REN , NEERAJ JAGDISH AGRAWAL , RICHARD SMITH
CPC分类号: C07K16/40 , C07K16/2869 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/90 , C07K2317/92 , C07K2317/94 , G01N11/14
摘要: The present invention concerns a method for preparing antigen binding proteins specific for PCSK9 with reduced viscosity. The method proceeds by replacing residues in high viscosity variable domain subfamilies with residues in correlating low viscosity subfamilies. The method further comprises substituting residues in the Fc domain with residues associated with low viscosity and adding charged residues to the C-terminus of the Fc domain. The present invention further concerns antigen binding proteins produced by this method.
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公开(公告)号:US20240336685A1
公开(公告)日:2024-10-10
申请号:US17281896
申请日:2019-09-27
申请人: AMGEN INC.
IPC分类号: C07K16/28
CPC分类号: C07K16/2809 , C07K16/2803 , C07K16/2878 , C07K2317/10 , C07K2317/31
摘要: The invention disclosed herein relates to methods for reducing aggregation of bispecific antibodies, for example reducing aggregation of bispecific T cell engager (BiTE) antibody constructs, resulting from storage under frozen conditions by holding the antibodies at certain temperatures after thaw.
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公开(公告)号:US20240327461A1
公开(公告)日:2024-10-03
申请号:US18497081
申请日:2024-06-11
申请人: AMGEN INC.
发明人: Jerry Ryan HOLDER , Gayathri SWAMINATH , Michael J. FROHN , Brian Alan LANMAN , Anthony B. REED , Leslie P. MIRANDA , John Gordon ALLEN , Alexander J. PICKRELL , Aaron C. SIEGMUND , Lewis D. PENNINGTON , Bryant YANG
CPC分类号: C07K7/08 , A61K38/10 , A61K47/542 , A61K47/60 , C07K14/47 , A61K38/00 , C07K2319/30
摘要: The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.
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公开(公告)号:US12104995B2
公开(公告)日:2024-10-01
申请号:US16635941
申请日:2018-08-01
申请人: AMGEN INC.
发明人: Chao-Hsiang Wu
CPC分类号: G01N1/34 , G01N33/6848 , G01N2001/385
摘要: Systems, and methods that facilitate the performance of an assay of a sample substantially in real-time. Thus, the assay can be performed, and the desired result obtained, much more quickly than allowed by conventional systems and methods.
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公开(公告)号:US20240314190A1
公开(公告)日:2024-09-19
申请号:US18577109
申请日:2022-07-20
申请人: AMGEN INC.
IPC分类号: H04L65/80 , H04N21/236 , H04N21/472 , H04N23/62 , H04N23/661
CPC分类号: H04L65/80 , H04N21/236 , H04N21/472 , H04N23/62 , H04N23/661
摘要: A telepresence system may include at least one telepresence device including a digital camera having camera control inputs and a video feed output. The system may also include at least one remote device having a web browser. The camera control inputs may be communicated from the remote device to the at least one telepresence device via an embedded webserver. The video feed output may be communicated to the remote device via a video server configured to transmit real-time video data from the digital camera, over a secure socket connection, to the remote device.
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