公开(公告)号：US20230167130A1

公开(公告)日：2023-06-01

申请号：US17922619

申请日：2021-05-05

Applicant: AMGEN INC.

Inventor： Austin G. SMITH ,  Jason S. TEDROW ,  Gabrielle ST-PIERRE ,  Oliver Ralf THIEL ,  Liang HUANG ,  Philipp C. ROOSEN ,  John T. COLYER ,  Kyle D. BAUCOM ,  Ari ERICSON ,  Matthew G. BEAVER ,  Rahul P. SANGODKAR ,  Michael A. LOVETTE ,  Robert Ronald MILBURN ,  Alan H. CHERNEY ,  Sheng CUI

IPC: C07D513/10 ,  C07D267/16

CPC classification number: C07D513/10 ,  C07D267/16

Abstract: Provided herein are processes for synthesizing Mcl-1 inhibitors and intermediates such as compound F that can be used to prepare them where the variable PG is as defined herein. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.

公开(公告)号：US20230183164A1

公开(公告)日：2023-06-15

申请号：US17920084

申请日：2021-05-04

Applicant: AMGEN INC.

Inventor： Austin G. SMITH ,  Michael T. CORBETT ,  Neil Fred LANGILLE ,  Kyle D. BAUCOM ,  Peter K. DORNAN ,  Gabrielle ST- PIERRE ,  Philipp C. ROOSEN ,  Sheng CUI ,  Roberto PROFETA

IPC: C07C67/62 ,  C07D249/18 ,  C07D519/00 ,  C07D513/08

CPC classification number: C07C67/62 ,  C07D249/18 ,  C07D519/00 ,  C07D513/08 ,  C07B2200/13

Abstract: Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound F, or a salt thereof, wherein R1 and OPG2 are described herein. Compound F can be useful in synthesizing compound A1, or a salt of solvate thereof, and compound A2, or a salt of solvate thereof.