公开(公告)号：US20220372070A1

公开(公告)日：2022-11-24

申请号：US17773886

申请日：2020-11-04

Applicant: AMGEN INC.

Inventor： Luis DIAZ ,  Natalia R. GOMEZ

IPC: C07K1/18 ,  C07K16/06

Abstract: The invention relates to high salt load conditioning during cation exchange chromatography for removal of low isoelectric point product-related impurities during manufacture of recombinant multispecific proteins.

公开(公告)号：US20220372071A1

公开(公告)日：2022-11-24

申请号：US17773892

申请日：2020-11-04

Applicant: AMGEN INC.

Inventor： Malhar R. AMBHAIKAR ,  Luis DIAZ ,  Natalia R. GOMEZ ,  Benjamin J. TILLOTSON

IPC: C07K1/18 ,  C07K16/46 ,  B01D15/36 ,  B01D15/42 ,  B01D15/38 ,  B01D61/14

Abstract: The invention relates to methods for removal of low isoelectric point product-related impurities during cation exchange purification operations.