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公开(公告)号：US20220249778A1
公开(公告)日：2022-08-11
申请号：US17627008
申请日：2020-07-16
申请人： AMGEN INC.
摘要： A drug delivery device includes a housing releasably coupled with a patient, a container disposed in the housing, a plunger disposed in the container, an activation mechanism, and a seal member. The container includes a wall with an interior surface. The plunger includes an interior surface and is moveably disposed in the container. The interior surfaces of the wall and the plunger define a reservoir adapted to contain a drug. The activation mechanism is adapted to release a drive fluid for moving the plunger through the container to expel the drug therefrom. The seal member is moveably disposed in the container and is adapted to inhibit ingress of the drive fluid into the reservoir.
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公开(公告)号：US20240100247A1
公开(公告)日：2024-03-28
申请号：US17767466
申请日：2020-10-01
申请人： AMGEN INC.
发明人： Tohid Pirbodaghi , Joshua Tamsky , Paul Daniel Faucher , Jeff Lind , Scott R. Gibson , Sheldon B. Moberg , Samin Akbari
CPC分类号： A61M5/14248 , A61M5/1454 , A61M5/16881 , A61M39/26 , A61M2005/14252
摘要： A drug delivery device includes a housing, a container disposed in the housing, an activation mechanism, a needle insertion mechanism, and a fluid flow path. The container has an inner volume to contain a medicament which is urged out of the container by the activation mechanism. The needle insertion mechanism includes an actuation assembly adapted to insert a needle and a cannula to deliver the medicament from the container and a valve assembly. The fluid flow connection is coupled with the container and the needle insertion mechanism and is adapted to allow the medicament to flow from the container to the needle insertion mechanism. The valve assembly is repeatedly movable between at least a valve open position and a valve closed position to selectively allow and restrict the medicament to flow through the needle and/or the cannula.
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公开(公告)号：US20220355025A1
公开(公告)日：2022-11-10
申请号：US17641458
申请日：2020-10-05
申请人： AMGEN INC.
发明人： Tohid Pirbodaghi , Samin Akbari , Joshua Tamsky , Paul Daniel Faucher , Scott Robert Gibson , Sheldon B. Moberg
摘要： A drug delivery device includes a housing, a container disposed in the housing, an activation mechanism, and a needle insertion mechanism (NIM). The container has an inner volume to contain a medicament which is urged out of the container by the activation mechanism. The needle insertion mechanism (NIM) is operably coupled with the activation mechanism and includes an actuation assembly adapted to insert a needle and a cannula to deliver the medicament from the container. The actuation assembly is movable between a storage state, a first operational state, a second operational state, and a third operational state to selectively position the needle and the cannula.
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公开(公告)号：US20200164155A1
公开(公告)日：2020-05-28
申请号：US16630329
申请日：2018-08-07
申请人： AMGEN INC.
摘要： A wearable drug delivery device includes a housing, a needle assembly at least partially disposed in the housing, and a drive assembly at least partially disposed in the housing and coupled to the needle assembly. The needle assembly includes a needle or cannula and a sterile barrier disposed proximal to the needle or cannula in a first configuration where the sterile barrier is intact. The drive assembly includes a container that contains a medicament to be administered, a first plunger disposed in the container, and a drive mechanism that forces the first plunger to urge the medicament through the container. Upon engaging the drive mechanism, the needle or cannula and the sterile barrier move relative to each other from the first configuration to a second configuration where the needle or cannula breaks the sterile barrier, thereby allowing the medicament to be administered via the needle or cannula.
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公开(公告)号：US20220288305A1
公开(公告)日：2022-09-15
申请号：US17626667
申请日：2020-07-16
申请人： AMGEN INC.
摘要： A drug delivery device includes a housing releasably coupled with a patient, a pressure chamber disposed in the housing and including a vent, a container at least partially disposed in the pressure chamber for storing a drug connectable in fluid communication with a fluid conduit, an activation mechanism, and a relief mechanism. The activation mechanism releases a pressurized drive fluid into the pressure chamber for expelling the drug from the container into the fluid conduit. The relief mechanism is operably coupled to the fluid conduit and is adapted to open the vent to release the drive fluid from the pressure chamber in response to a predetermined condition.
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公开(公告)号：US20220062543A1
公开(公告)日：2022-03-03
申请号：US17419406
申请日：2020-02-11
申请人： AMGEN INC.
摘要： A drug delivery system includes a delivery container including a container body adapted to accommodate a drug therein, a supply line, and a flow rate monitor. The delivery container further includes inlet and outlet ports and is constructed from a resilient material that exerts an urging force on the drug to expel the drug from the outlet port. The supply line is operably coupled to the outlet port to deliver the drug to a user. The flow rate monitor is operably coupled to at least one of the delivery container or the supply line and includes a digital controller, a fluid valve operably coupled to the digital controller, and a translating syringe in fluid communication with the fluid valve and operably coupled to the digital controller. The fluid valve, the translating piston, and the digital controller cooperate to regulate a flow rate of the drug.
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公开(公告)号：US20240066215A1
公开(公告)日：2024-02-29
申请号：US17767471
申请日：2020-10-14
申请人： AMGEN INC.
发明人： Scott R. Gibson , Mehran Mojarrad , Paul Daniel Faucher , Steven Edward Gorski , Nicholas D.M. Prsha , Eduardo Ho , Rafi Muhammad Sufi
CPC分类号： A61M5/145 , A61M5/1723
摘要： A drug delivery device for delivering a medicament includes a pump first housing, a pump second housing, an inlet fluid path, and an outlet fluid path. The pump first housing is at least partially supporting and/or surrounding a fluid displacement assembly. The pump second housing is at least partially supporting and/or surrounding a drive component for driving the fluid displacement assembly. The inlet fluid path is configured to deliver medicament to the fluid displacement assembly. The outlet fluid path is configured to receive medicament from the fluid displacement assembly. The pump first housing and the pump second housing are removably coupled with each other.
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公开(公告)号：US20210228797A1
公开(公告)日：2021-07-29
申请号：US17256240
申请日：2019-07-12
申请人： AMGEN INC.
发明人： Matthew Wayne Janke , Sudeshna Dutta Ray , Scott R. Gibson , Daniel Eduardo Groszmann , Wael Mismar , Mehran Mojarrad , Robert Allen Dees , Paul Daniel Faucher
摘要： Fluid path assemblies for drug delivery devices and methods of establishing a fluid flow path for drug delivery devices are described that include a needle shield valve member that couples to a reservoir having a needle mounted thereto. The needle shield valve member includes an internal barrier that protects the needle and/or contains a drug within the reservoir until activation of the drug delivery device. Upon activation, there is relative movement between the reservoir and needle shield valve member until the needle pierces the barrier to establish a fluid flow path from the reservoir through the needle shield valve member.
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