公开(公告)号：US20140099670A1

公开(公告)日：2014-04-10

申请号：US13843987

申请日：2013-03-15

Applicant: AMGEN INC.

Inventor： Paul KOSTENUIK ,  Wenyan SHEN ,  Thomas C. BOONE

IPC: C07K16/24

CPC classification number: C07K16/241 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2227/105 ,  A01K2267/03 ,  A61K2039/505 ,  C07K14/635 ,  C07K14/70575 ,  C07K16/2875 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2319/00

Abstract: Chimeric molecules comprising receptor activator of NF-κB ligand (RANKL) antibodies and parathyroid hormone/parathyroid hormone-related protein (PTH/PTHrP) peptides are described. Compositions and methods for the treatment of bone diseases are also described.

Abstract translation: 描述了包含NF-κB配体（RANKL）抗体和甲状旁腺激素/甲状旁腺激素相关蛋白（PTH / PTHrP）肽的受体激活剂的嵌合分子。 还描述了用于治疗骨疾病的组合物和方法。

公开(公告)号：US20180105589A1

公开(公告)日：2018-04-19

申请号：US15696138

申请日：2017-09-05

Applicant: AMGEN INC.

Inventor： Thomas M. DILLON ,  Pavel BONDARENKO ,  Jette WYPYCH ,  Martin J. ALLEN ,  Alain BALLAND ,  Margaret Speed RICCI ,  Amy GUO ,  Wenyan SHEN ,  Jeonghoon SUN ,  Christopher J. VEZINA

IPC: C07K16/24 ,  C07K16/28 ,  C07K16/00

CPC classification number: C07K16/245 ,  C07K16/00 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/2875 ,  C07K2317/53 ,  C07K2317/56

Abstract: The present invention is generally directed to methods of producing an increase in the enrichment and/or recovery of preferred forms of monoclonal antibodies. More particularly, the invention relates to methods for eliminating disulfide heterogeneity in the hinge region of recombinant IgG2 antibody proteins.