公开(公告)号：US11466078B2

公开(公告)日：2022-10-11

申请号：US16267758

申请日：2019-02-05

Applicant: Amgen Inc.

Inventor： Gunasekaran Kannan ,  Monica Florio ,  Zhi Liu ,  Wei Yan

IPC: C07K16/46 ,  C07K16/22 ,  C07K16/18 ,  C07K16/28 ,  C07K16/32 ,  A61K39/00

Abstract: The present application is directed to heterodimeric antibodies and methods of use.

公开(公告)号：US09822173B2

公开(公告)日：2017-11-21

申请号：US14443107

申请日：2013-11-21

Applicant: AMGEN INC.

Inventor： Gunasekaran Kannan ,  Monica Florio ,  Zhi Liu ,  Wei Yan

IPC: A61K39/00 ,  A61K39/395 ,  C07K16/22 ,  C07K16/18 ,  C07K16/28 ,  C07K16/32 ,  C07K16/46

CPC classification number: C07K16/22 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/2863 ,  C07K16/32 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00

Abstract: The present application is directed to heterodimeric antibodies and methods of use.

公开(公告)号：US11198732B2

公开(公告)日：2021-12-14

申请号：US16413810

申请日：2019-05-16

Applicant: AMGEN INC.

Inventor： Zhi Liu ,  Gunasekaran Kannan ,  Wei Yan

IPC: C07K16/00 ,  C12P21/08 ,  A61K39/395 ,  A61K39/40 ,  C07K16/28 ,  A61K45/06 ,  C07K1/00

Abstract: Disclosed are Fc-containing proteins comprising a binding region and a variant Fc region that can elicit one or more immune effector function and/or bind to an Fc receptor more effectively than a similar Fc-containing protein comprising a wild type Fc region. Also disclosed are nucleic acids encoding such Fc-containing proteins, methods for making such proteins, and methods of treatment utilizing such proteins.

公开(公告)号：US20190153086A1

公开(公告)日：2019-05-23

申请号：US16267758

申请日：2019-02-05

Applicant: Amgen Inc.

Inventor： Gunasekaran Kannan ,  Monica Florio ,  Zhi Liu ,  Wei Yan

IPC: C07K16/22 ,  C07K16/46 ,  C07K16/28 ,  C07K16/32 ,  C07K16/18

Abstract: The present application is directed to heterodimeric antibodies and methods of use.

公开(公告)号：US20140154254A1

公开(公告)日：2014-06-05

申请号：US14086190

申请日：2013-11-21

Applicant: AMGEN INC.

Inventor： Gunasekaran Kannan ,  Monica Florio ,  Zhi Liu ,  Wei Yan

IPC: C07K16/46 ,  C07K16/18

CPC classification number: C07K16/22 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/2863 ,  C07K16/32 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00

Abstract: The present application is directed to heterodimeric antibodies and methods of use.

Abstract translation: 本申请涉及异二聚体抗体和使用方法。

公开(公告)号：US10233237B2

公开(公告)日：2019-03-19

申请号：US14086190

申请日：2013-11-21

Applicant: AMGEN INC.

Inventor： Gunasekaran Kannan ,  Monica Florio ,  Zhi Liu ,  Wei Yan

IPC: C07K16/18 ,  C07K16/28 ,  C07K16/46 ,  C07K16/22 ,  C07K16/32 ,  A61K39/00

Abstract: The present application is directed to heterodimeric antibodies and methods of use.