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公开(公告)号：US20240174745A1
公开(公告)日：2024-05-30
申请号：US18316739
申请日：2023-05-12
发明人： Christoph Dahlhoff , Claudia Blümel , Johannes Brozy , Tobias Raum , Elisabeth Nahrwold , Tara Arvedson , Irwin Chen , Sandra Ross , Julie Bailis
CPC分类号： C07K16/28 , A61P35/00 , C07K16/2809 , A61K2039/505 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to an antibody construct comprising a domain which binds to Claudin 18.2 (CLDN18.2) and another domain which binds to CD3. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for producing the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20210130465A1
公开(公告)日：2021-05-06
申请号：US16956797
申请日：2018-12-31
发明人： Tobias Raum , Tara Arvedson , Julie Bailis , Christoph Dahlhoff , Sandra Ross , Irwin Chen , Claudia Blümel , Elisabeth Nahrwold , Jochen Pendzialek , Joachim Wahl
摘要： The present invention provides bispecific antibody constructs characterized by comprising a first domain binding to MUC17, a second domain binding to an extracellular epitope of the human and the Macaca CD3E chain and optionally a third domain, which is a specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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公开(公告)号：US11692031B2
公开(公告)日：2023-07-04
申请号：US16530006
申请日：2019-08-02
发明人： Christoph Dahlhoff , Claudia Blümel , Johannes Brozy , Tobias Raum , Elisabeth Nahrwold , Tara Arvedson , Irwin Chen , Sandra Ross , Julie Bailis
CPC分类号： C07K16/28 , A61P35/00 , C07K16/2809 , A61K2039/505 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to an antibody construct comprising a domain which binds to Claudin 18.2 (CLDN18.2) and another domain which binds to CD3. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for producing the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20200055932A1
公开(公告)日：2020-02-20
申请号：US16530006
申请日：2019-08-02
发明人： Christoph Dahlhoff , Claudia Blümel , Johannes Brozy , Tobias Raum , Elisabeth Nahrwold , Tara Arvedson , Irwin Chen , Sandra Ross , Julie Bailis
摘要： The present invention relates to an antibody construct comprising a domain which binds to Claudin 18.2 (CLDN18.2) and another domain which binds to CD3. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for producing the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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