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公开(公告)号：US11692031B2
公开(公告)日：2023-07-04
申请号：US16530006
申请日：2019-08-02
发明人： Christoph Dahlhoff , Claudia Blümel , Johannes Brozy , Tobias Raum , Elisabeth Nahrwold , Tara Arvedson , Irwin Chen , Sandra Ross , Julie Bailis
CPC分类号： C07K16/28 , A61P35/00 , C07K16/2809 , A61K2039/505 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to an antibody construct comprising a domain which binds to Claudin 18.2 (CLDN18.2) and another domain which binds to CD3. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for producing the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20200055932A1
公开(公告)日：2020-02-20
申请号：US16530006
申请日：2019-08-02
发明人： Christoph Dahlhoff , Claudia Blümel , Johannes Brozy , Tobias Raum , Elisabeth Nahrwold , Tara Arvedson , Irwin Chen , Sandra Ross , Julie Bailis
摘要： The present invention relates to an antibody construct comprising a domain which binds to Claudin 18.2 (CLDN18.2) and another domain which binds to CD3. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for producing the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20240174745A1
公开(公告)日：2024-05-30
申请号：US18316739
申请日：2023-05-12
发明人： Christoph Dahlhoff , Claudia Blümel , Johannes Brozy , Tobias Raum , Elisabeth Nahrwold , Tara Arvedson , Irwin Chen , Sandra Ross , Julie Bailis
CPC分类号： C07K16/28 , A61P35/00 , C07K16/2809 , A61K2039/505 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to an antibody construct comprising a domain which binds to Claudin 18.2 (CLDN18.2) and another domain which binds to CD3. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for producing the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20210130465A1
公开(公告)日：2021-05-06
申请号：US16956797
申请日：2018-12-31
发明人： Tobias Raum , Tara Arvedson , Julie Bailis , Christoph Dahlhoff , Sandra Ross , Irwin Chen , Claudia Blümel , Elisabeth Nahrwold , Jochen Pendzialek , Joachim Wahl
摘要： The present invention provides bispecific antibody constructs characterized by comprising a first domain binding to MUC17, a second domain binding to an extracellular epitope of the human and the Macaca CD3E chain and optionally a third domain, which is a specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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公开(公告)号：US11186636B2
公开(公告)日：2021-11-30
申请号：US16500378
申请日：2018-04-20
申请人： AMGEN INC.
发明人： Ian Foltz , Shilpa Sambashivan , Irwin Chen , Susie Miki Harris , Dora Toledo Warshaviak , Ian Driver , Daniel Lu
摘要： The present invention relates to antigen binding proteins, such as monoclonal antibodies, that specifically bind to and activate human triggering receptor expressed on myeloid cells-2 (TREM2) and pharmaceutical compositions comprising such antigen binding proteins. The agonist antigen binding proteins (e.g. antibodies) of the invention are capable of activating TREM2/DAP12 signaling in myeloid cells in the absence of Fc-mediated cross-linking of the antigen binding proteins. Methods of treating or preventing conditions associated with TREM2 loss of function, such as Alzheimer's disease and multiple sclerosis, using the antigen binding proteins are also described.
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公开(公告)号：US20210054069A1
公开(公告)日：2021-02-25
申请号：US16500378
申请日：2018-04-20
申请人： AMGEN INC.
发明人： Ian Foltz , Shilpa Sambashivan , Irwin Chen , Susie Miki Harris , Dora Toledo Warshaviak , Ian Driver , Daniel Lu
摘要： The present invention relates to antigen binding proteins, such as monoclonal antibodies, that specifically bind to and activate human triggering receptor expressed on myeloid cells-2 (TREM2) and pharmaceutical compositions comprising such antigen binding proteins. The agonist antigen binding proteins (e.g. antibodies) of the invention are capable of activating TREM2/DAP12 signaling in myeloid cells in the absence of Fc-mediated cross-linking of the antigen binding proteins. Methods of treating or preventing conditions associated with TREM2 loss of function, such as Alzheimer's disease and multiple sclerosis, using the antigen binding proteins are also described.
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公开(公告)号：US09708375B2
公开(公告)日：2017-07-18
申请号：US14776917
申请日：2014-03-14
申请人： AMGEN INC.
发明人： Ryan B. Case , Benjamin M. Alba , Alice Bakker , Irwin Chen , Amy N. Duguay , Monica Florio , Peng Li , Mark Leo Michaels , Mei-Mei Tsai
IPC分类号： C07K14/435 , C07K16/18 , C07K14/51 , A61K47/48
CPC分类号： C07K14/435 , A61K47/60 , C07K14/51 , C07K16/18 , C07K2319/31
摘要： The present application is directed to avimers and peptides and various combinations thereof in addition to methods of making and using them.
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公开(公告)号：US11643440B2
公开(公告)日：2023-05-09
申请号：US16619874
申请日：2018-06-01
申请人： AMGEN INC.
发明人： Irwin Chen , Su Chong , Essa Hu Harrington , Fang-Tsao Hong , Jason C. Long , Leslie P. Miranda
CPC分类号： C07K14/001 , A61P25/06 , A61K38/00
摘要： Novel peptides that bind to human PAC1 are provided. These peptides that are antagonists of PAC1 are useful in a number of PAC1 related disorders, including the treatment and/or prevention of headache disorders, including migraine, such as acute migraine.
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