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公开(公告)号：US11926666B2
公开(公告)日：2024-03-12
申请号：US17306051
申请日：2021-05-03
发明人： Bertram Weiss , Anna-Lena Frisk , Ruprecht Zierz , Peter Kufer , Tobias Raum , Doris Rau , Jonas Anlahr , Ralf Lutterbüse , Lisa Nahrwold , Christoph Dahlhoff , Claudia Blümel , Patrick Hoffmann
CPC分类号： C07K16/2809 , A61P35/00 , C07K16/28 , C07K16/3053 , A61K2039/505 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to a bispecific antibody construct comprising a first human binding domain which binds to human CDH3 on the surface of a target cell and a second binding domain which binds to human CDS on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20180142021A1
公开(公告)日：2018-05-24
申请号：US15566444
申请日：2016-04-18
发明人： Bertram Weiss , Ann-Lena Frisk , Ruprecht Zierz , Peter Kufer , Tobias Raum , Doris Rau , Jonas Anlahr , Ralf Lutterbüse , Lisa Nahrwold , Christoph Dahlhoff , Claudia Blümel , Patrick Hoffmann
CPC分类号： C07K16/2809 , A61K2039/505 , A61P35/00 , C07K16/28 , C07K16/3053 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to a bispecific antibody construct comprising a first human binding domain which binds to human CDH3 on the surface of a target cell and a second binding domain which binds to human CDS on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20230041876A1
公开(公告)日：2023-02-09
申请号：US17306051
申请日：2021-05-03
发明人： Bertram Weiss , Ann-Lena Frisk , Ruprecht Zierz , Peter Kufer , Tobias Raum , Doris Rau , Jonas Anlahr , Ralf Lutterbüse , Lisa Nahrwold , Christoph Dahlhoff , Claudia Blümel , Patrick Hoffmann
摘要： The present invention relates to a bispecific antibody construct comprising a first human binding domain which binds to human CDH3 on the surface of a target cell and a second binding domain which binds to human CDS on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US11028171B2
公开(公告)日：2021-06-08
申请号：US15566444
申请日：2016-04-18
发明人： Bertram Weiss , Ann-Lena Frisk , Ruprecht Zierz , Peter Kufer , Tobias Raum , Doris Rau , Jonas Anlahr , Ralf Lutterbüse , Lisa Nahrwold , Christoph Dahlhoff , Claudia Blümel , Patrick Hoffmann
摘要： The present invention relates to a bispecific antibody construct comprising a first human binding domain which binds to human CDH3 on the surface of a target cell and a second binding domain which binds to human CDS on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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