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1.发明授权Compositions and uses of antimicrobial materials with tissue-compatible properties 有权具有组织相容性质的抗菌材料的组成和用途公开(公告)号：US09446090B2
公开(公告)日：2016-09-20
申请号：US14385752
申请日：2013-03-15
申请人： AMICROBE, INC.
IPC分类号： A61K45/06 , A61K38/02 , A61K38/16 , A61K9/06 , A61L15/42 , A61L15/46 , A61L24/00 , A61K31/715 , A61K31/765 , A01N37/46 , A01N37/44
CPC分类号： A61K38/16 , A01N37/44 , A01N37/46 , A01N47/44 , A61K9/06 , A61K31/715 , A61K31/765 , A61K38/02 , A61K45/06 , A61L15/42 , A61L15/46 , A61L24/001 , A61L24/0015 , A61L24/0036 , A61L2400/04 , Y02A50/473 , A01N25/10
摘要： Compositions comprising a mixture of an antimicrobial cationic polypeptide and a second pharmaceutically-acceptable polymer are disclosed, as well as methods and uses thereof for the treatment and prevention of infections that occur when our natural barriers of defense are broken.
摘要翻译： 公开了包含抗微生物阳离子多肽和第二药学上可接受的聚合物的混合物的组合物，以及其治疗和预防当我们的天然防御屏障被破坏时发生的感染的方法和用途。
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2.发明申请COMPOSITIONS AND USES OF MATERIALS WITH HIGH ANTIMICROBIAL ACTIVITY AND LOW TOXICITY 有权具有高抗微生物活性和低毒性的材料的组合物和用途公开(公告)号：US20130267458A1
公开(公告)日：2013-10-10
申请号：US13776221
申请日：2013-02-25
CPC分类号： A01N37/18 , A23L3/3526 , A61K9/0019 , A61K9/107 , A61K38/02 , A61K38/16 , A61K45/06 , A61K47/02 , C07K14/001 , Y02A50/473
摘要： Improved synthetic copolypeptide antimicrobials contain cationic amino acid residues and may be based on a blocky sequence. These antimicrobials show low mammalian toxicity and may undergo directed self-assembly. The inventive synthetic copolypeptides are useful in treatment of wounds and other infections.
摘要翻译： 改进的合成共聚肽抗微生物剂含有阳离子氨基酸残基并且可以基于嵌段序列。 这些抗微生物剂显示出低的哺乳动物毒性，并且可以进行定向自组装。 本发明的合成共聚肽可用于治疗伤口和其它感染。
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公开(公告)号：US20230012691A1
公开(公告)日：2023-01-19
申请号：US17684267
申请日：2022-03-01
申请人： Amicrobe, Inc.
IPC分类号： A61K38/16 , A01N37/46 , A01N37/44 , A61L15/42 , A61L15/46 , A61L24/00 , A61K9/06 , A61K31/715 , A61K31/765 , A61K38/02 , A61K45/06 , A01N47/44
摘要： Compositions comprising a mixture of an antimicrobial cationic polypeptide and a second pharmaceutically-acceptable polymer are disclosed, as well as methods and uses thereof for the treatment and prevention of infections that occur when our natural barriers of defense are broken.
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4.发明申请COMPOSITIONS AND USES OF ANTIMICROBIAL MATERIALS WITH TISSUE-COMPATIBLE PROPERTIES 有权具有组织相容性的抗菌材料的组成和用途公开(公告)号：US20150080290A1
公开(公告)日：2015-03-19
申请号：US14385752
申请日：2013-03-15
申请人： AMICROBE, INC.
IPC分类号： A61K38/02 , A61K31/765 , A61K45/06 , A61K31/715
CPC分类号： A61K38/16 , A01N37/44 , A01N37/46 , A01N47/44 , A61K9/06 , A61K31/715 , A61K31/765 , A61K38/02 , A61K45/06 , A61L15/42 , A61L15/46 , A61L24/001 , A61L24/0015 , A61L24/0036 , A61L2400/04 , Y02A50/473 , A01N25/10
摘要： Compositions comprising a mixture of an antimicrobial cationic polypeptide and a second pharmaceutically-acceptable polymer are disclosed, as well as methods and uses thereof for the treatment and prevention of infections that occur when our natural barriers of defense are broken.
摘要翻译： 公开了包含抗微生物阳离子多肽和第二药学上可接受的聚合物的混合物的组合物，以及其治疗和预防当我们的天然防御性障碍被破坏时发生的感染的方法和用途。
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公开(公告)号：US12016898B2
公开(公告)日：2024-06-25
申请号：US17684267
申请日：2022-03-01
申请人： Amicrobe, Inc.
IPC分类号： A61K38/16 , A01N37/44 , A01N37/46 , A01N47/44 , A61K9/06 , A61K31/715 , A61K31/765 , A61K38/02 , A61K45/06 , A61L15/42 , A61L15/46 , A61L24/00
CPC分类号： A61K38/16 , A01N37/44 , A01N37/46 , A01N47/44 , A61K9/06 , A61K31/715 , A61K31/765 , A61K38/02 , A61K45/06 , A61L15/42 , A61L15/46 , A61L24/001 , A61L24/0015 , A61L24/0036 , A61L2400/04 , Y02A50/30 , A01N37/44 , A01N25/10 , A01N37/46 , A01N25/10
摘要： Compositions comprising a mixture of an antimicrobial cationic polypeptide and a second pharmaceutically-acceptable polymer are disclosed, as well as methods and uses thereof for the treatment and prevention of infections that occur when our natural barriers of defense are broken.
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公开(公告)号：US11298401B2
公开(公告)日：2022-04-12
申请号：US15240197
申请日：2016-08-18
申请人： AMICROBE, INC.
IPC分类号： A61K38/16 , A01N37/46 , A01N37/44 , A61L15/42 , A61L15/46 , A61L24/00 , A61K9/06 , A61K31/715 , A61K31/765 , A61K38/02 , A61K45/06 , A01N47/44
摘要： Compositions comprising a mixture of an antimicrobial cationic polypeptide and a second pharmaceutically-acceptable polymer are disclosed, as well as methods and uses thereof for the treatment and prevention of infections that occur when our natural barriers of defense are broken.
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公开(公告)号：US20200288709A1
公开(公告)日：2020-09-17
申请号：US16658861
申请日：2019-10-21
IPC分类号： A01N37/18 , A23L3/3526 , A61K38/02 , A61K9/00 , A61K47/02 , A61K9/107 , A61K38/16 , A61K45/06 , C07K14/00
摘要： Improved synthetic copolypeptide antimicrobials contain cationic amino acid residues and may be based on a blocky sequence. These antimicrobials show low mammalian toxicity and may undergo directed self-assembly. The inventive synthetic copolypeptides are useful in treatment of wounds and other infections.
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8.发明授权Compositions and uses of materials with high antimicrobial activity and low toxicity 有权具有高抗微生物活性和低毒性的材料的组成和用途公开(公告)号：US09017730B2
公开(公告)日：2015-04-28
申请号：US13776221
申请日：2013-02-25
IPC分类号： A61K9/14 , A61P43/00 , C07K14/00 , A23L3/3526 , A61K38/02 , A61K9/00 , A61K47/02 , A61K9/107 , A01N37/18 , A61K38/16 , A61K45/06
CPC分类号： A01N37/18 , A23L3/3526 , A61K9/0019 , A61K9/107 , A61K38/02 , A61K38/16 , A61K45/06 , A61K47/02 , C07K14/001 , Y02A50/473
摘要： Improved synthetic copolypeptide antimicrobials contain cationic amino acid residues and may be based on a blocky sequence. These antimicrobials show low mammalian toxicity and may undergo directed self-assembly. The inventive synthetic copolypeptides are useful in treatment of wounds and other infections.
摘要翻译： 改进的合成共聚肽抗微生物剂含有阳离子氨基酸残基并且可以基于嵌段序列。 这些抗微生物剂显示出低的哺乳动物毒性，并且可以进行定向自组装。 本发明的合成共聚肽可用于治疗伤口和其它感染。
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公开(公告)号：US10448634B2
公开(公告)日：2019-10-22
申请号：US14693601
申请日：2015-04-22
IPC分类号： A01N37/18 , A23L3/3526 , A61K38/02 , A61K9/00 , A61K47/02 , A61K9/107 , A61K38/16 , A61K45/06 , C07K14/00
摘要： Improved synthetic copolypeptide antimicrobials contain cationic amino acid residues and may be based on a blocky sequence. These antimicrobials show low mammalian toxicity and may undergo directed self-assembly. The inventive synthetic copolypeptides are useful in treatment of wounds and other infections.
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10.发明申请COMPOSITIONS AND USES OF ANTIMICROBIAL MATERIALS WITH TISSUE-COMPATIBLE PROPERTIES 审中-公开具有组织相容性的抗菌材料的组成和用途公开(公告)号：US20170042965A1
公开(公告)日：2017-02-16
申请号：US15240197
申请日：2016-08-18
申请人： AMICROBE, INC.
CPC分类号： A61K38/16 , A01N37/44 , A01N37/46 , A01N47/44 , A61K9/06 , A61K31/715 , A61K31/765 , A61K38/02 , A61K45/06 , A61L15/42 , A61L15/46 , A61L24/001 , A61L24/0015 , A61L24/0036 , A61L2400/04 , Y02A50/473 , A01N25/10
摘要： Compositions comprising a mixture of an antimicrobial cationic polypeptide and a second pharmaceutically-acceptable polymer are disclosed, as well as methods and uses thereof for the treatment and prevention of infections that occur when our natural barriers of defense are broken.
摘要翻译： 公开了包含抗微生物阳离子多肽和第二药学上可接受的聚合物的混合物的组合物，以及其治疗和预防当我们的天然防御性障碍被破坏时发生的感染的方法和用途。
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