公开(公告)号：US20180078522A1

公开(公告)日：2018-03-22

申请号：US15563119

申请日：2016-03-28

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyun Jung KIM ,  Ji Hyun KIM ,  Jue Won KIM ,  Ho Sik RHO ,  Hyun Seo KANG

IPC: A61K31/351 ,  A61Q19/00 ,  A61K8/49

CPC classification number: A61K31/351 ,  A61K8/498 ,  A61K31/35 ,  A61K31/36 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08

Abstract: Disclosed is a composition for activating longevity genes, particularly, a Sirt-1, Klotho, XPD, ERCC8 or FoxO3a gene, containing a kojic acid derivative as an active ingredient. The composition activates longevity genes, thereby having anticancer, lifetime extension, skin moisturization or skin barrier strengthening effects.

公开(公告)号：US20170326100A1

公开(公告)日：2017-11-16

申请号：US15534625

申请日：2015-11-26

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyun Seo KANG ,  Hyoung June KIM ,  Se Jin YOO ,  Ji Hyun KIM

IPC: A61K31/353 ,  A61Q19/08 ,  A61K8/49

CPC classification number: A61K31/353 ,  A61K8/49 ,  A61K8/498 ,  A61K8/9783 ,  A61Q19/08

Abstract: Disclosed is a composition for activating one or more genes of an XPD gene, a Klotho gene, a Sirt-1 gene, an ERCC8 gene and a FoxO3 gene, which contains a methylated catechin, a salt thereof, a prodrug thereof, a hydrate thereof, a solvate thereof or an isomer thereof as an active ingredient. In an aspect, the present disclosure provides a pharmaceutical composition, a cosmetic composition or a food composition which activates one or more genes of an XPD gene, a Klotho gene, a Sirt-1 gene, an ERCC8 gene and a FoxO3 gene and is useful in preventing or treating disease related with the genes, preventing aging and improving skin.