公开(公告)号：US12059467B2

公开(公告)日：2024-08-13

申请号：US18278416

申请日：2022-08-24

Applicant: ANHUI UNIVERSITY

Inventor： Rupei Tang ,  Guoqing Yan ,  Xin Wang

IPC: A61K47/22 ,  A61K31/337 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/445 ,  A61K38/28 ,  A61K38/38 ,  A61K47/34 ,  C07D317/34

CPC classification number: A61K47/22 ,  A61K31/337 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/445 ,  A61K38/28 ,  A61K38/38 ,  A61K47/34 ,  C07D317/34

Abstract: An improved low-toxicity and high-efficiency orthoester mixture pharmaceutical adjuvant, a preparation method thereof, and a topical sustained release drug delivery formulation including the same are provided. The improved low-toxicity and high-efficiency orthoester mixture pharmaceutical adjuvant is obtained by mixing methoxy-free orthoester compounds (classes I and II) in different proportions or mixing an orthoester compound (class I or II) with a biocompatible medical polymer material in different proportions, where an orthoester compound of class I has a chemical formula shown in formula I:




and an orthoester compound of class II has a chemical formula shown in formula II:





The present disclosure has the following beneficial effects: In the present disclosure, the biosafety of the pharmaceutical adjuvant is improved by adjusting a substituent type and a length of an orthoester compound, and the properties of the orthoester mixture pharmaceutical adjuvant do not change before and after the improvement.