公开(公告)号：US20230113948A1

公开(公告)日：2023-04-13

申请号：US17787089

申请日：2020-12-17

Applicant: ARBUTUS BIOPHARMA CORPORATION

Inventor： Mahesh PALLERLA ,  Ganapati Reddy PAMULAPATI ,  Jan SPINK

IPC: A61K47/54 ,  C07D491/048 ,  C07D207/08 ,  C07C213/08 ,  C07H1/00 ,  C07H15/08 ,  C07C231/12 ,  C07C231/02 ,  C07D207/46 ,  C07C201/12 ,  C07C227/04 ,  C07C231/10 ,  C07C237/06 ,  C07C237/16 ,  C12N15/113 ,  A61K45/06

Abstract: The invention provides synthetic processes and synthetic intermediate compounds that can be used to prepare therapeutic conjugates. The invention also provides methods for treating HBV and/or HDV infection in a human by administering a therapeutic conjugate prepared by the synthetic methods of the invention.