公开(公告)号：US20240360067A1

公开(公告)日：2024-10-31

申请号：US18682780

申请日：2022-08-11

申请人： Sitryx Therapeutics Limited

发明人： Michael Liam COOKE ,  Matthew Colin Thor FYFE ,  Alessandro MAZZACANI

IPC分类号： C07C69/618 ,  A61K31/225 ,  A61K31/337 ,  A61K31/351 ,  A61K31/38 ,  A61K31/381 ,  A61K31/4164 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/5375 ,  C07C235/76 ,  C07C237/16 ,  C07D211/58 ,  C07D213/55 ,  C07D233/64 ,  C07D295/15 ,  C07D305/08 ,  C07D309/14 ,  C07D331/04 ,  C07D333/24

CPC分类号： C07C69/618 ,  A61K31/225 ,  A61K31/337 ,  A61K31/351 ,  A61K31/38 ,  A61K31/381 ,  A61K31/4164 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/5375 ,  C07C235/76 ,  C07C237/16 ,  C07D211/58 ,  C07D213/55 ,  C07D233/64 ,  C07D295/15 ,  C07D305/08 ,  C07D309/14 ,  C07D331/04 ,  C07D333/24 ,  C07C2601/04 ,  C07C2601/16

摘要： The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response:






wherein RA and RB are as defined herein.

公开(公告)号：US11834393B2

公开(公告)日：2023-12-05

申请号：US17157522

申请日：2021-01-25

申请人： GIVAUDAN SA

发明人： Adri De Klerk ,  Cornelis Winkel

IPC分类号： C07C237/16 ,  C07C237/06 ,  C07C323/60 ,  C07C233/58 ,  A23L27/20 ,  A23L27/00 ,  C07C323/04 ,  C07D207/16 ,  C07C323/41

CPC分类号： C07C237/16 ,  A23L27/202 ,  A23L27/203 ,  A23L27/204 ,  A23L27/2022 ,  A23L27/2054 ,  A23L27/88 ,  C07C233/58 ,  C07C237/06 ,  C07C323/41 ,  C07C323/60 ,  C07D207/16 ,  A23V2002/00

摘要： This disclosure relates to flavour modification and to compounds of formula (I) or edible salts thereof,






wherein
R1 is selected from C6-C20 alkyl, and C9-C25 alkenyl, and

i) R3 and R4 are hydrogen and R2 the residue of a proteinogenic amino acid;
ii) R2 and R3 are methyl and R4 is hydrogen; or R4 is hydrogen and R2 and R3 form together with the carbon atom to which they are attached cyclopropyl;
iii) R2 is hydrogen, and R3 and R4 together are —CH2—CH2—CH2—






useful in modifying flavours.

公开(公告)号：US20230192607A1

公开(公告)日：2023-06-22

申请号：US17789023

申请日：2020-12-23

申请人： Dana-Farber Cancer Institute, Inc.

发明人： Nathanael S. Gray ,  Tinghu Zhang ,  Jianwei Che ,  Nicholas Paul Kwiatkowski ,  Mengyang Fan ,  Wenchao LU

IPC分类号： C07D207/14 ,  C07C311/46 ,  C07C237/42 ,  C07C237/44 ,  C07C237/16 ,  A61P35/00

CPC分类号： C07D207/14 ,  A61P35/00 ,  C07C237/16 ,  C07C237/42 ,  C07C237/44 ,  C07C311/46

摘要： Provided herein are compounds of (I-A), (I-B), or (II), and pharmaceutically acceptable salts, solvates, hydrates, poly-morphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. Also provided are methods, uses, and kits involving the inventive compounds and pharmaceutical compositions thereof for treating and/or preventing diseases (e.g., proliferative diseases (e.g., cancers), inflammatory diseases (e.g., fibrosis), autoimmune diseases (e.g., sclerosis)) in a subject. Provided are methods of inhibiting the activity of a transcription factor (e.g., TEAD, such as TEAD1, TEAD2, TEAD3, TEAD4) and/or inhibiting the transcription of a gene (e.g., a gene controlled or regulated by a transcription factor (e.g., TEAD)) in a subject.

公开(公告)号：US20230132932A1

公开(公告)日：2023-05-04

申请号：US18052231

申请日：2022-11-03

申请人： KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

发明人： Syed M. Shakil HUSSAIN ,  Muhammad Shahzad KAMAL ,  Abdullah S. SULTAN

IPC分类号： C07C237/16 ,  C09K8/584 ,  C07C381/06 ,  C11D1/00 ,  C07C233/36 ,  C07C233/38

摘要： The invention concerns synthesized amido-amine-based cationic gemini surfactants with flexible and rigid spacers and different hydrophobic. These gemini surfactants were prepared by modified procedure through amidation of long chain carboxylic acids using 3-(dimethylamino)-1-propylamine followed by treatment with halohydrocarbons and showed excellent thermal stability and surface properties useful for various oilfield applications such as enhanced oil recovery.

公开(公告)号：US20210371460A1

公开(公告)日：2021-12-02

申请号：US17149565

申请日：2021-01-14

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Peter Wipf ,  Marie-Celine Frantz

IPC分类号： C07K5/08 ,  A61K31/454 ,  C07D211/58 ,  C07D401/12 ,  A61K47/64 ,  C07D417/12 ,  C07C237/16 ,  C07D209/46 ,  C07D211/94 ,  C07D221/22 ,  C07D209/44 ,  C07D279/06 ,  C07D471/08

摘要： Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.

公开(公告)号：US10745346B2

公开(公告)日：2020-08-18

申请号：US15754838

申请日：2016-08-31

申请人： Kuen-Feng Chen ,  Chung-Wai Shiau

发明人： Kuen-Feng Chen ,  Chung-Wai Shiau

IPC分类号： C07C275/36 ,  C07C235/82 ,  C07C237/16 ,  C07C317/26 ,  A61K31/155 ,  C07C237/24 ,  C07D265/36 ,  C07D213/84 ,  C07D401/12

摘要： Some novel compounds are provided in this disclosure. These novel compounds have potential SHP-1 agonist activity for being used in treating cancer.

公开(公告)号：US20180092971A1

公开(公告)日：2018-04-05

申请号：US15617520

申请日：2017-06-08

申请人： Arbutus Biopharma Corporation

发明人： Muthiah Manoharan ,  Muthusamy Jayaraman ,  Kallanthottathil G. Rajeev ,  Laxman Eltepu ,  Steven Ansell ,  Jianxin Chen

IPC分类号： A61K39/39 ,  A61K9/127 ,  A61K31/713 ,  A61K39/00 ,  A61K47/10 ,  A61K47/18 ,  A61K47/20 ,  A61K47/28 ,  C07C229/08 ,  C07C229/30 ,  C07C237/16 ,  C07C251/38 ,  C07C251/78 ,  C07C271/12 ,  C07C271/20 ,  C07C323/25 ,  C07D203/10 ,  C07D317/28 ,  C07D319/06 ,  C12N15/11 ,  C12N15/113

摘要： The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure XXXIII, wherein: R1 and R2 are each independently for each occurrence optionally substituted C10-C30 alkyl, optionally substituted C10-C30 alkenyl, optionally substituted C10-C30 alkynyl, optionally substituted C10-C30 acyl, or -linker-ligand; R3 is H, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ω-aminoalkyls, ω-(substituted)aminoalkyls, ω-phosphoalkyls, ω-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand; and E is C(O)O or OC(O).

公开(公告)号：US20180022757A1

公开(公告)日：2018-01-25

申请号：US15639833

申请日：2017-06-30

申请人： Gilead Sciences, Inc.

发明人： Anna Chiu ,  John Enquist, JR. ,  Nolan Griggs ,  Christopher Hale ,  Norihiro Ikemoto ,  Katie Ann Keaton ,  Matt Kraft ,  Scott E. Lazerwith ,  Michel Leeman ,  Zhihui Peng ,  Kate Schrier ,  Jonathan Trinidad ,  Jochem Van Herpt ,  Andrew W. Waltman

IPC分类号： C07D498/14 ,  C07D213/82 ,  C07C237/20 ,  C07D319/06 ,  C07C237/16 ,  C07D309/40 ,  C07C235/80 ,  C07C231/02 ,  C07D498/22 ,  C07C231/12

摘要： Methods of making compounds of Formula I are disclosed:

公开(公告)号：US09175246B2

公开(公告)日：2015-11-03

申请号：US13878981

申请日：2011-10-25

申请人： Dave R. Allen ,  Marcos Alonso ,  Randal J. Bernhardt ,  Aaron Brown ,  Kelly Buchek ,  Gary Luebke ,  Renee Luka ,  Andrew D. Malec ,  Ronald A. Masters ,  Lawrence A. Munie ,  Dennis S. Murphy ,  Irene Shapiro ,  Patti Skelton ,  Brian Sook ,  Michael R. Terry ,  Laura Lee Whitlock ,  Michael Wiester ,  Patrick Shane Wolfe

发明人： Dave R. Allen ,  Marcos Alonso ,  Randal J. Bernhardt ,  Aaron Brown ,  Kelly Buchek ,  Gary Luebke ,  Renee Luka ,  Andrew D. Malec ,  Ronald A. Masters ,  Lawrence A. Munie ,  Dennis S. Murphy ,  Irene Shapiro ,  Patti Skelton ,  Brian Sook ,  Michael R. Terry ,  Laura Lee Whitlock ,  Michael Wiester ,  Patrick Shane Wolfe

IPC分类号： C07C237/16 ,  C07C211/21 ,  C07C231/12 ,  C07C303/18 ,  C11C3/08 ,  C11D1/28 ,  C11D1/74 ,  C11D1/94 ,  C08K5/20 ,  C07C67/26 ,  C07C41/03 ,  C07C43/11 ,  C07C6/04 ,  C07C69/533 ,  C07C69/593 ,  B01F17/00 ,  C11D1/83 ,  A01N25/04 ,  A01N33/12 ,  A01N37/18 ,  A01N37/44 ,  A01N41/04 ,  A61K8/41 ,  A61K8/42 ,  A61K8/44 ,  A61K8/46 ,  A61Q5/12 ,  A61Q19/10 ,  A62D1/02 ,  C11D1/62 ,  C11D1/92 ,  C11D1/04 ,  A01N25/02 ,  A61K8/92 ,  C08K5/01 ,  C11C3/00 ,  C11D3/48 ,  C07C219/08 ,  A01N25/30 ,  C07C209/12 ,  C11D1/00 ,  C08G65/26 ,  C07C309/14 ,  C11C1/02 ,  C09K8/00 ,  C09K15/28 ,  C11D1/90 ,  C11D1/65

CPC分类号： C11D1/66 ,  A01N25/02 ,  A01N25/04 ,  A01N25/30 ,  A01N33/12 ,  A01N37/18 ,  A01N37/44 ,  A01N41/04 ,  A01N57/20 ,  A61K8/41 ,  A61K8/416 ,  A61K8/42 ,  A61K8/44 ,  A61K8/466 ,  A61K8/92 ,  A61Q5/12 ,  A61Q19/10 ,  A62D1/0071 ,  B01F17/0028 ,  B01F17/0057 ,  C04B24/121 ,  C04B24/124 ,  C04B24/16 ,  C04B28/02 ,  C04B28/14 ,  C04B38/10 ,  C07C6/04 ,  C07C41/03 ,  C07C43/11 ,  C07C67/26 ,  C07C69/533 ,  C07C69/593 ,  C07C209/12 ,  C07C211/21 ,  C07C219/08 ,  C07C231/12 ,  C07C237/16 ,  C07C303/18 ,  C07C309/69 ,  C08G65/2615 ,  C08K5/01 ,  C08K5/17 ,  C08K5/20 ,  C08K5/32 ,  C08K5/42 ,  C09D5/00 ,  C09D7/63 ,  C09K8/00 ,  C09K8/54 ,  C09K8/584 ,  C09K15/28 ,  C09K2208/32 ,  C11C3/00 ,  C11C3/08 ,  C11D1/002 ,  C11D1/04 ,  C11D1/28 ,  C11D1/62 ,  C11D1/652 ,  C11D1/74 ,  C11D1/75 ,  C11D1/83 ,  C11D1/90 ,  C11D1/92 ,  C11D1/94 ,  C11D3/48 ,  C07C211/63 ,  C07C211/64 ,  C07C233/38 ,  C07C309/14 ,  A01N33/18 ,  A01N39/04 ,  A01N43/653 ,  A01N51/00 ,  A01N43/40 ,  A01N43/56 ,  A01N53/00 ,  C07C11/02

摘要： Fatty amine compositions made from a metathesis-derived C10-C17 monounsaturated acid, octadecene-1,18-dioic acid, or their ester derivatives are disclosed. In another aspect, fatty amidoamines made by reacting a metathesis-derived C10-C17 monounsaturated acid, octadecene-1,18-dioic acid, or their ester derivatives with an aminoalkyl-substituted tertiary amine are disclosed. The fatty amines or amidoamines are advantageously sulfonated, sulfitated, oxidized, or reduced. In other aspects, the ester derivative is a modified triglyceride made by self-metathesis of a natural oil or an unsaturated triglyceride made by cross-metathesis of a natural oil with an olefin.

摘要翻译： 公开了由复分解衍生的C10-C17单不饱和酸，十八碳烯-1,18-二酸或其酯衍生物制成的脂肪胺组合物。 另一方面，公开了通过使由复分解衍生的C10-C17单不饱和酸，十八烯-1,18-二酸或其酯衍生物与氨基烷基取代的叔胺反应制得的脂肪酰氨基胺。 脂肪胺或酰胺胺有利地被磺化，硫酸化，氧化或还原。 在其它方面，酯衍生物是通过天然油或不饱和甘油三酸酯通过天然油与烯烃的交叉复分解而制备的改性甘油三酸酯。

公开(公告)号：US09006144B2

公开(公告)日：2015-04-14

申请号：US13880017

申请日：2011-10-25

申请人： Dave R. Allen ,  Randal J. Bernhardt ,  Andrew D. Malec ,  Patrick Shane Wolfe

发明人： Dave R. Allen ,  Randal J. Bernhardt ,  Andrew D. Malec ,  Patrick Shane Wolfe

IPC分类号： A01N57/18 ,  A01N57/00 ,  A61K31/66 ,  C11C3/08 ,  C07C69/533 ,  C07C69/593 ,  C11D1/28 ,  C11D1/74 ,  B01F17/00 ,  C11D1/83 ,  C11D1/94 ,  C07C211/21 ,  C07C237/16 ,  A01N25/04 ,  A01N33/12 ,  A01N37/18 ,  A01N37/44 ,  A01N41/04 ,  A61K8/41 ,  A61K8/42 ,  A61K8/44 ,  A61K8/46 ,  A61Q5/12 ,  A61Q19/10 ,  A62D1/02 ,  C09K8/00 ,  C09K15/28 ,  C11D1/62 ,  C11D1/90 ,  C11D1/92 ,  C11D1/04 ,  A01N25/02 ,  A61K8/92 ,  C08K5/01 ,  C08K5/20 ,  C11C3/00 ,  C11D3/48 ,  C07C219/08 ,  A01N25/30 ,  C07C209/12 ,  C07C231/12 ,  C07C303/18 ,  C11D1/00 ,  C11D1/65 ,  C08G65/26

CPC分类号： C11C3/08 ,  A01N25/02 ,  A01N25/04 ,  A01N25/30 ,  A01N33/12 ,  A01N37/18 ,  A01N37/44 ,  A01N41/04 ,  A61K8/416 ,  A61K8/42 ,  A61K8/44 ,  A61K8/466 ,  A61K8/92 ,  A61Q5/12 ,  A61Q19/10 ,  A62D1/0071 ,  B01F17/0028 ,  B01F17/0057 ,  C07C69/533 ,  C07C69/593 ,  C07C209/12 ,  C07C211/21 ,  C07C219/08 ,  C07C231/12 ,  C07C237/16 ,  C07C303/18 ,  C08G65/2615 ,  C08K5/01 ,  C08K5/20 ,  C09K8/00 ,  C09K15/28 ,  C11C3/00 ,  C11D1/002 ,  C11D1/04 ,  C11D1/28 ,  C11D1/62 ,  C11D1/652 ,  C11D1/74 ,  C11D1/83 ,  C11D1/90 ,  C11D1/92 ,  C11D1/94 ,  C11D3/48 ,  C07C211/63 ,  C07C211/64 ,  C07C233/38 ,  C07C309/14 ,  A01N33/18 ,  A01N39/04 ,  A01N43/653 ,  A01N51/00 ,  A01N57/20 ,  A01N43/40 ,  A01N43/56 ,  A01N53/00

摘要： Aqueous glyphosate formulations comprising a surfactant derived from metathesized natural oil feedstocks are disclosed. The formulations comprise a glyphosate salt, water, and a surfactant derived from a metathesis-derived C10-C17 monounsaturated acid, octadecene-1,18-dioic acid, or their ester derivatives. The surfactant is selected from C10 or C12 amine oxides, C10 or C12 quats, C10, C12, or C16 amidoamines, C10 or C12 amidoamine oxides, C10 imidazoline quats, C10 or C12 amidoamine quats, C10, C12, or C16 betaines, C16 amidoamine betaines, C18 diamidoamines, C18 diamidoamine oxides, C18 diamidoamine diquats, C18 diamidoamine oxide quats, C18 diamidoamine oxide betaines, Cis diamidoamine monobetaines, C18 diamidoamine monobetaine quats, C18 ester amidoamine quats, and amidoamines and their oxidized or quaternized derivatives made from self- or cross-metathesized palm or soybean oil. The surfactants noted above impart substantial stability to highly concentrated glyphosate formulations at, above, and below room temperature and perform as well or better than commercial alternatives.

摘要翻译： 公开了包含衍生自复分解天然油原料的表面活性剂的含草甘膦水性制剂。 制剂包含草甘膦盐，水和衍生自复分解衍生的C10-C17单不饱和酸，十八碳烯-1,18-二酸或其酯衍生物的表面活性剂。 表面活性剂选自C10或C12胺氧化物，C10或C12季铵，C10，C12或C16酰氨基胺，C10或C12酰氨基胺氧化物，C10咪唑啉季铵，C10或C12酰氨基季铵，C10，C12或C16甜菜碱，C16酰氨基胺 甜菜碱，C18二酰氨基胺，C18二酰氨基胺氧化物，C18二酰氨基胺二铵，C18二酰氨基胺氧化物季铵，C18二酰氨基胺氧化甜菜碱，顺式二酰氨基胺一甜菜碱，C18二酰氨基胺单甜菜碱季铵，C18酯酰胺胺季铵和酰胺基胺及其氧化或季铵化衍生物， 交叉变性棕榈油或大豆油。 上述表面活性剂在高于和低于室温的情况下对高度浓缩的草甘膦制剂赋予了显着的稳定性，并且与商业替代物一样好或更好。