-
公开(公告)号：US11318098B2
公开(公告)日：2022-05-03
申请号：US17329755
申请日：2021-05-25
IPC分类号： A61K9/127 , A61K47/10 , A61K47/24 , A61K47/44 , A61K31/7088 , A61K31/7084
摘要： The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. The lipid solution preferably comprises an organic solvent, such as a lower alkanol.
-
公开(公告)号：US12129467B2
公开(公告)日：2024-10-29
申请号：US18410136
申请日：2024-01-11
发明人： Ed Yaworski , Lloyd B. Jeffs , Lorne R. Palmer
IPC分类号： C07H21/04 , A61K9/107 , A61K9/50 , A61K9/51 , A61K31/7088 , A61K31/7105 , A61K31/712 , A61K31/713 , A61K47/14 , A61K47/54 , C12N15/113 , C12N15/88 , A61K9/127
CPC分类号： C12N15/113 , A61K9/1075 , A61K9/5015 , A61K9/5123 , A61K31/7088 , A61K31/7105 , A61K31/712 , A61K31/713 , A61K47/14 , A61K47/543 , C12N15/88 , A61K9/1272 , A61K9/1274 , C12N2310/14 , C12N2310/321 , C12N2310/3515 , C12N2320/32
摘要： The present invention provides novel, stable lipid particles having a non-lamellar structure and comprising one or more active agents or therapeutic agents, methods of making such lipid particles, and methods of delivering and/or administering such lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (SNALP) that have a non-lamellar structure and that comprise a nucleic acid (such as one or more interfering RNA), methods of making the SNALP, and methods of delivering and/or administering the SNALP.
-
公开(公告)号：US12037587B2
公开(公告)日：2024-07-16
申请号：US18410136
申请日：2024-01-11
发明人： Ed Yaworski , Lloyd B. Jeffs , Lorne R. Palmer
IPC分类号： C07H21/04 , A61K9/107 , A61K9/50 , A61K9/51 , A61K31/7088 , A61K31/7105 , A61K31/712 , A61K31/713 , A61K47/14 , A61K47/54 , C12N15/113 , C12N15/88 , A61K9/127
CPC分类号： C12N15/113 , A61K9/1075 , A61K9/5015 , A61K9/5123 , A61K31/7088 , A61K31/7105 , A61K31/712 , A61K31/713 , A61K47/14 , A61K47/543 , C12N15/88 , A61K9/1272 , A61K9/1274 , C12N2310/14 , C12N2310/321 , C12N2310/3515 , C12N2320/32
摘要： The present invention provides novel, stable lipid particles having a non-lamellar structure and comprising one or more active agents or therapeutic agents, methods of making such lipid particles, and methods of delivering and/or administering such lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (SNALP) that have a non-lamellar structure and that comprise a nucleic acid (such as one or more interfering RNA), methods of making the SNALP, and methods of delivering and/or administering the SNALP.
-
公开(公告)号：US20210207140A1
公开(公告)日：2021-07-08
申请号：US17203572
申请日：2021-03-16
发明人： Ed Yaworski , Lloyd B. Jeffs , Lorne R. Palmer
IPC分类号： C12N15/113 , A61K47/54 , A61K9/107 , A61K9/51 , A61K31/7088 , A61K31/7105 , A61K31/712 , A61K31/713 , C12N15/88 , A61K47/14 , A61K9/50
摘要： The present invention provides novel, stable lipid particles having a non-lamellar structure and comprising one or more active agents or therapeutic agents, methods of making such lipid particles, and methods of delivering and/or administering such lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (SNALP) that have a non-lamellar structure and that comprise a nucleic acid (such as one or more interfering RNA), methods of making the SNALP, and methods of delivering and/or administering the SNALP.
-
公开(公告)号：US20240035030A1
公开(公告)日：2024-02-01
申请号：US18330590
申请日：2023-06-07
发明人： Ed Yaworski , Lloyd B. Jeffs , Lorne R. Palmer
IPC分类号： C12N15/113 , A61K47/54 , A61K9/107 , A61K9/51 , A61K31/7088 , A61K31/7105 , A61K31/712 , A61K31/713 , C12N15/88 , A61K47/14 , A61K9/50
CPC分类号： C12N15/113 , A61K47/543 , A61K9/1075 , A61K9/5123 , A61K31/7088 , A61K31/7105 , A61K31/712 , A61K31/713 , C12N15/88 , A61K47/14 , A61K9/5015 , A61K9/1272
摘要： The present invention provides novel, stable lipid particles having a non-lamellar structure and comprising one or more active agents or therapeutic agents, methods of making such lipid particles, and methods of delivering and/or administering such lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (SNALP) that have a non-lamellar structure and that comprise a nucleic acid (such as one or more interfering RNA), methods of making the SNALP, and methods of delivering and/or administering the SNALP.
-
公开(公告)号：US11718852B2
公开(公告)日：2023-08-08
申请号：US17203572
申请日：2021-03-16
发明人： Ed Yaworski , Lloyd B. Jeffs , Lorne R. Palmer
IPC分类号： C07H21/04 , C12N15/113 , A61K47/54 , A61K9/107 , A61K9/51 , A61K31/7088 , A61K31/7105 , A61K31/712 , A61K31/713 , C12N15/88 , A61K47/14 , A61K9/50 , A61K9/127
CPC分类号： C12N15/113 , A61K9/1075 , A61K9/5015 , A61K9/5123 , A61K31/7088 , A61K31/712 , A61K31/713 , A61K31/7105 , A61K47/14 , A61K47/543 , C12N15/88 , A61K9/1272 , A61K9/1274 , C12N2310/14 , C12N2310/321 , C12N2310/3515 , C12N2320/32
摘要： The present invention provides novel, stable lipid particles having a non-lamellar structure and comprising one or more active agents or therapeutic agents, methods of making such lipid particles, and methods of delivering and/or administering such lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (SNALP) that have a non-lamellar structure and that comprise a nucleic acid (such as one or more interfering RNA), methods of making the SNALP, and methods of delivering and/or administering the SNALP.
-
公开(公告)号：US11298320B2
公开(公告)日：2022-04-12
申请号：US17330209
申请日：2021-05-25
IPC分类号： A61K9/127 , A61K47/10 , A61K47/24 , A61K47/44 , A61K31/7088 , A61K31/7084
摘要： The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. The lipid solution preferably comprises an organic solvent, such as a lower alkanol.
-
公开(公告)号：US20210275455A1
公开(公告)日：2021-09-09
申请号：US17330209
申请日：2021-05-25
IPC分类号： A61K9/127 , A61K47/10 , A61K47/24 , A61K47/44 , A61K31/7088 , A61K31/7084
摘要： The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. The lipid solution preferably comprises an organic solvent, such as a lower alkanol.
-
公开(公告)号：US20210275454A1
公开(公告)日：2021-09-09
申请号：US17329755
申请日：2021-05-25
IPC分类号： A61K9/127 , A61K47/10 , A61K47/24 , A61K47/44 , A61K31/7088 , A61K31/7084
摘要： The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. The lipid solution preferably comprises an organic solvent, such as a lower alkanol.
-
公开(公告)号：US20240182895A1
公开(公告)日：2024-06-06
申请号：US18410136
申请日：2024-01-11
发明人： Ed Yaworski , Lloyd B. Jeffs , Lorne R. Palmer
IPC分类号： C12N15/113 , A61K9/107 , A61K9/127 , A61K9/50 , A61K9/51 , A61K31/7088 , A61K31/7105 , A61K31/712 , A61K31/713 , A61K47/14 , A61K47/54 , C12N15/88
CPC分类号： C12N15/113 , A61K9/1075 , A61K9/5015 , A61K9/5123 , A61K31/7088 , A61K31/7105 , A61K31/712 , A61K31/713 , A61K47/14 , A61K47/543 , C12N15/88 , A61K9/1272 , A61K9/1274 , C12N2310/14 , C12N2310/321 , C12N2310/3515 , C12N2320/32
摘要： The present invention provides novel, stable lipid particles having a non-lamellar structure and comprising one or more active agents or therapeutic agents, methods of making such lipid particles, and methods of delivering and/or administering such lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (SNALP) that have a non-lamellar structure and that comprise a nucleic acid (such as one or more interfering RNA), methods of making the SNALP, and methods of delivering and/or administering the SNALP.
-
-
-
-
-
-
-
-
-
搜索结果
13 条记录 (耗时 0.019 秒)
