公开(公告)号：US20230110295A1

公开(公告)日：2023-04-13

申请号：US17854575

申请日：2022-06-30

申请人： ARBUTUS BIOPHARMA CORPORATION

发明人： James HEYES ,  Richard J. HOLLAND ,  Adam JUDGE ,  Amy C. H. LEE ,  Alan D. MARTIN ,  Nicholas Michael SNEAD ,  Emily P. THI ,  Mark WOOD ,  Xin YE

IPC分类号： C12N15/113

摘要： The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).