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公开(公告)号：US20190282604A1
公开(公告)日：2019-09-19
申请号：US16068243
申请日：2017-01-06
IPC分类号： A61K31/713 , A61K31/4375 , A61K31/18 , A61K31/5377 , A61K31/675 , A61P31/20 , A61K31/7068 , A61K31/352
摘要： The invention provides therapeutic combinations and therapeutic methods that are useful for treating Hepatitis B.
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公开(公告)号：US20220168430A1
公开(公告)日：2022-06-02
申请号：US17440480
申请日：2020-03-19
发明人： Andrzej ARDZINSKI , Andrea CUCONATI , Amy C. H. LEE , Nagraj MANI , Cornelis A. RIJNBRAND , Michael J. SOFIA , Emily P. THI
IPC分类号： A61K47/55 , A61K47/60 , A61K38/21 , A61K31/675 , A61K31/522 , A61K31/4196 , A61K31/4375 , A61K31/7088 , A61K47/54 , A61P31/20
摘要： The invention provides therapeutic combinations and therapeutic methods that are useful for treating Hepatitis B and Hepatitis D.
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公开(公告)号：US20210047640A1
公开(公告)日：2021-02-18
申请号：US16850819
申请日：2020-04-16
发明人： Ting CHIU , Narayanan HARIHARAN , Amy C. H. LEE , Christopher Justin PASETKA , Janet Ruth PHELPS , Nicholas Michael SNEAD , Andrew Anthony WIECZOREK
IPC分类号： C12N15/113 , A61P3/06
摘要： The present invention provides compositions comprising therapeutic nucleic acids such as siRNA that target ApoC3 and ANGPTL3 expression, lipid particles comprising one or more (e.g., a combination) of the therapeutic nucleic acids, and methods of delivering and/or administering the lipid particles (e.g., for treating hypertriglyceridemia in humans).
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公开(公告)号：US20230110295A1
公开(公告)日：2023-04-13
申请号：US17854575
申请日：2022-06-30
发明人： James HEYES , Richard J. HOLLAND , Adam JUDGE , Amy C. H. LEE , Alan D. MARTIN , Nicholas Michael SNEAD , Emily P. THI , Mark WOOD , Xin YE
IPC分类号： C12N15/113
摘要： The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).
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公开(公告)号：US20230212578A1
公开(公告)日：2023-07-06
申请号：US18072202
申请日：2022-11-30
发明人： Ting CHIU , Narayanan HARIHARAN , Amy C. H. LEE , Christopher Justin PASETKA , Janet Ruth PHELPS , Nicholas Michael SNEAD , Andrew Anthony WIECZOREK
IPC分类号： C12N15/113 , A61P3/06
CPC分类号： C12N15/113 , C12N15/1136 , A61P3/06 , C12N2310/14 , C12N2320/32 , C12N2320/31 , C12N2310/32 , C12N2310/321 , C12N2310/33 , C12N2310/3515
摘要： The present invention provides compositions comprising therapeutic nucleic acids such as siRNA that target ApoC3 and ANGPTL3 expression, lipid particles comprising one or more (e.g., a combination) of the therapeutic nucleic acids, and methods of delivering and/or administering the lipid particles (e.g., for treating hypertriglyceridemia in humans).
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公开(公告)号：US20220265817A1
公开(公告)日：2022-08-25
申请号：US16617384
申请日：2018-05-31
发明人： Amy C. H. LEE , Emily P. THI
IPC分类号： A61K39/29 , A61K39/395 , A61P31/20
摘要： The invention provides therapeutic combinations and therapeutic methods that are useful for treating hepatitis B.
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公开(公告)号：US20240052349A1
公开(公告)日：2024-02-15
申请号：US18035695
申请日：2021-11-05
发明人： Owen M. DALY , Amy C. H. LEE , Michael J. SOFIA , Emily P. THI
IPC分类号： C12N15/113 , A61K47/54 , A61K45/06 , A61P31/20
CPC分类号： C12N15/1131 , A61K47/549 , A61K45/06 , A61P31/20
摘要： The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, an siRNA, and optional linking groups. The conjugates are useful to target siRNA.
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公开(公告)号：US20240050463A1
公开(公告)日：2024-02-15
申请号：US18071353
申请日：2022-11-29
IPC分类号： A61K31/713 , A61P31/20 , A61K31/18 , A61K31/352 , A61K31/4375 , A61K31/5377 , A61K31/675 , A61K31/7068
CPC分类号： A61K31/713 , A61P31/20 , A61K31/18 , A61K31/352 , A61K45/06 , A61K31/5377 , A61K31/675 , A61K31/7068 , A61K31/4375
摘要： The invention provides therapeutic combinations and therapeutic methods that are useful for treating Hepatitis B.
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公开(公告)号：US20180208932A1
公开(公告)日：2018-07-26
申请号：US15748080
申请日：2016-07-28
IPC分类号： C12N15/113 , A61K9/127 , A61K31/713 , A61P31/20
CPC分类号： C12N15/1131 , A61K9/1272 , A61K31/713 , A61P31/20 , C12N2310/14 , C12N2310/32 , C12N2320/31 , C12N2320/32 , C12N2310/321 , C12N2310/3521
摘要： The present invention provides compositions comprising therapeutic nucleic acids such as siRNA that target Hepatitis B virus (HBV) gene expression, lipid particles comprising one or more (e.g., a combination) of the therapeutic nucleic acids, and methods of delivering and/or administering the lipid particles (e.g., for treating HBV infection and/or HDV infection in humans).
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