公开(公告)号：US20220168430A1

公开(公告)日：2022-06-02

申请号：US17440480

申请日：2020-03-19

申请人： ARBUTUS BIOPHARMA CORPORATION

发明人： Andrzej ARDZINSKI ,  Andrea CUCONATI ,  Amy C. H. LEE ,  Nagraj MANI ,  Cornelis A. RIJNBRAND ,  Michael J. SOFIA ,  Emily P. THI

IPC分类号： A61K47/55 ,  A61K47/60 ,  A61K38/21 ,  A61K31/675 ,  A61K31/522 ,  A61K31/4196 ,  A61K31/4375 ,  A61K31/7088 ,  A61K47/54 ,  A61P31/20

摘要： The invention provides therapeutic combinations and therapeutic methods that are useful for treating Hepatitis B and Hepatitis D.

公开(公告)号：US20220265817A1

公开(公告)日：2022-08-25

申请号：US16617384

申请日：2018-05-31

申请人： ARBUTUS BIOPHARMA CORPORATION

发明人： Amy C. H. LEE ,  Emily P. THI

IPC分类号： A61K39/29 ,  A61K39/395 ,  A61P31/20

摘要： The invention provides therapeutic combinations and therapeutic methods that are useful for treating hepatitis B.

公开(公告)号：US20230110295A1

公开(公告)日：2023-04-13

申请号：US17854575

申请日：2022-06-30

申请人： ARBUTUS BIOPHARMA CORPORATION

发明人： James HEYES ,  Richard J. HOLLAND ,  Adam JUDGE ,  Amy C. H. LEE ,  Alan D. MARTIN ,  Nicholas Michael SNEAD ,  Emily P. THI ,  Mark WOOD ,  Xin YE

IPC分类号： C12N15/113

摘要： The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).

公开(公告)号：US20240052349A1

公开(公告)日：2024-02-15

申请号：US18035695

申请日：2021-11-05

申请人： ARBUTUS BIOPHARMA CORPORATION

发明人： Owen M. DALY ,  Amy C. H. LEE ,  Michael J. SOFIA ,  Emily P. THI

IPC分类号： C12N15/113 ,  A61K47/54 ,  A61K45/06 ,  A61P31/20

CPC分类号： C12N15/1131 ,  A61K47/549 ,  A61K45/06 ,  A61P31/20

摘要： The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, an siRNA, and optional linking groups. The conjugates are useful to target siRNA.

公开(公告)号：US20180208932A1

公开(公告)日：2018-07-26

申请号：US15748080

申请日：2016-07-28

申请人： ARBUTUS BIOPHARMA CORPORATION

发明人： Amy C. H. LEE ,  Nicholas Michael SNEAD ,  Emily P. THI

IPC分类号： C12N15/113 ,  A61K9/127 ,  A61K31/713 ,  A61P31/20

CPC分类号： C12N15/1131 ,  A61K9/1272 ,  A61K31/713 ,  A61P31/20 ,  C12N2310/14 ,  C12N2310/32 ,  C12N2320/31 ,  C12N2320/32 ,  C12N2310/321 ,  C12N2310/3521

摘要： The present invention provides compositions comprising therapeutic nucleic acids such as siRNA that target Hepatitis B virus (HBV) gene expression, lipid particles comprising one or more (e.g., a combination) of the therapeutic nucleic acids, and methods of delivering and/or administering the lipid particles (e.g., for treating HBV infection and/or HDV infection in humans).