公开(公告)号：US20240043892A1

公开(公告)日：2024-02-08

申请号：US18345379

申请日：2023-06-30

Applicant: Arcturus Therapeutics, Inc.

Inventor： Maher ALAYYOUBI ,  Kyoung-Joo Jenny CHOI ,  Timothy Wayne LUGER, II

IPC: C12P19/34 ,  C12N9/10 ,  C12N9/12

CPC classification number: C12P19/34 ,  C12N9/1007 ,  C12Y201/01 ,  C12N9/1247 ,  C12Y207/07006

Abstract: Disclosed herein are methods of producing transcribed RNA product with increased yield and reduced dsRNA impurities.

公开(公告)号：US20220306678A1

公开(公告)日：2022-09-29

申请号：US17619882

申请日：2020-06-17

Applicant: ARCTURUS THERAPEUTICS, INC.

Inventor： Maher ALAYYOUBI ,  Jared Henry DAVIS

IPC: C07H21/02 ,  C12N15/10 ,  B01D15/38 ,  B01D15/42

Abstract: Provided herein are methods for purification of RNA from a sample. The methods include obtaining a first sample including double stranded RNA in a loading buffer, loading the sample onto a ceramic hydroxyapatite column, washing the column with wash buffer, and eluting the column with an elution buffer to create an eluate.