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公开(公告)号：US10969350B2
公开(公告)日：2021-04-06
申请号：US16616189
申请日：2018-05-22
发明人： Alexandra Ros , Daihyun Kim , Austin Echelmeier , Jorvani Cruz Villarreal , Ana Egatz-Gomez , Sebastian Quintana
IPC分类号： F16K11/02 , G01N23/20025 , B33Y80/00 , B01L3/02 , B01L3/00
摘要： Methods and systems are provided for serial femtosecond crystallography for reducing the vast amount of waste of injected crystals practiced with traditional continuous flow injections. A micrometer-scale 3-D printed water-in-oil droplet generator device includes an oil phase inlet channel, an aqueous phase inlet channel, a droplet flow outlet channel, and two embedded non-contact electrodes. The inlet and outlet channels are connected internally at a junction. The electrodes comprise gallium metal injected within the 3-D printed device. Voltage across the electrodes generates water-in-oil droplets, determines a rate for a series of droplets, or triggers a phase shift in the droplets. An external trigger generates the droplets based on the frequency of an XFEL utilized in droplet detection, thereby synchronizing a series of droplets with x-ray pulses for efficient crystal detection. The generated droplets can be coupled to an SFX with XFEL experiment compatible with common liquid injector such as a GDVN.
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公开(公告)号：US11867644B2
公开(公告)日：2024-01-09
申请号：US17220357
申请日：2021-04-01
发明人： Alexandra Ros , Daihyun Kim , Austin Echelmeier , Jorvani Cruz Villarreal , Ana Egatz-Gomez , Sebastian Quintana
IPC分类号： G01N23/20025 , B33Y80/00 , B01L3/02 , B01L3/00
CPC分类号： G01N23/20025 , B01L3/0241 , B01L3/50273 , B33Y80/00 , B01L2300/0867 , G01N2223/602
摘要： Methods and systems are provided for serial femtosecond crystallography for reducing the vast amount of waste of injected crystals practiced with traditional continuous flow injections. A micrometer-scale 3-D printed water-in-oil droplet generator device includes an oil phase inlet channel, an aqueous phase inlet channel, a droplet flow outlet channel, and two embedded non-contact electrodes. The inlet and outlet channels are connected internally at a junction. The electrodes comprise gallium metal injected within the 3-D printed device. Voltage across the electrodes generates water-in-oil droplets, determines a rate for a series of droplets, or triggers a phase shift in the droplets. An external trigger generates the droplets based on the frequency of an XFEL utilized in droplet detection, thereby synchronizing a series of droplets with x-ray pulses for efficient crystal detection. The generated droplets can be coupled to an SFX with XFEL experiment compatible with common liquid injector such as a GDVN.
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公开(公告)号：US12123840B2
公开(公告)日：2024-10-22
申请号：US18504091
申请日：2023-11-07
发明人： Alexandra Ros , Daihyun Kim , Austin Echelmeier , Jorvani Cruz Villarreal , Ana Egatz-Gomez , Sebastian Quintana
IPC分类号： G01N23/20025 , B01L3/00 , B01L3/02 , B33Y80/00
CPC分类号： G01N23/20025 , B01L3/0241 , B01L3/50273 , B33Y80/00 , B01L2300/0867 , G01N2223/602
摘要： Methods and systems are provided for serial femtosecond crystallography for reducing the vast amount of waste of injected crystals practiced with traditional continuous flow injections. A micrometer-scale 3-D printed water-in-oil droplet generator device includes an oil phase inlet channel, an aqueous phase inlet channel, a droplet flow outlet channel, and two embedded non-contact electrodes. The inlet and outlet channels are connected internally at a junction. The electrodes comprise gallium metal injected within the 3-D printed device. Voltage across the electrodes generates water-in-oil droplets, determines a rate for a series of droplets, or triggers a phase shift in the droplets. An external trigger generates the droplets based on the frequency of an XFEL utilized in droplet detection, thereby synchronizing a series of droplets with x-ray pulses for efficient crystal detection. The generated droplets can be coupled to an SFX with XFEL experiment compatible with common liquid injector such as a GDVN.
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