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公开(公告)号：US20240253044A1
公开(公告)日：2024-08-01
申请号：US18376276
申请日：2023-10-03
Applicant: 10x Genomics, Inc.
Inventor： Rajiv BHARADWAJ , Anthony MAKAREWICZ , Bill Kengli LIN
IPC: B01L3/00 , B01F23/41 , B01F25/314 , B01F31/80 , B01F33/3011 , B01F33/302 , B01L3/02 , C12Q1/6806 , C12Q1/686 , C40B40/06 , G01N33/543 , G01N33/58
CPC classification number: B01L3/502784 , B01F23/41 , B01F23/4105 , B01F25/3141 , B01F25/31422 , B01F25/31423 , B01F31/84 , B01F33/3011 , B01F33/3021 , B01L3/0241 , B01L3/50273 , B01L3/502761 , C12Q1/6806 , G01N33/54313 , G01N33/58 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2300/0851 , B01L2300/161 , B01L2400/086 , C12N2533/50 , C12Q1/686 , C12Q2563/185 , C40B40/06
Abstract: Devices, systems, and their methods of use, for generating droplets are provided. One or more geometric parameters of a microfluidic channel can be selected to generate droplets of a desired and predictable droplet size.
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2.发明公开公开(公告)号：US20240068965A1
公开(公告)日：2024-02-29
申请号：US18504091
申请日：2023-11-07
Inventor： Alexandra ROS , Daihyun KIM , Austin ECHELMEIER , Jorvani CRUZ VILLARREAL , Ana EGATZ-GOMEZ , Sebastian QUINTANA
IPC: G01N23/20025 , B01L3/00 , B01L3/02 , B33Y80/00
CPC classification number: G01N23/20025 , B01L3/0241 , B01L3/50273 , B33Y80/00 , B01L2300/0867 , G01N2223/602
Abstract: Methods and systems are provided for serial femtosecond crystallography for reducing the vast amount of waste of injected crystals practiced with traditional continuous flow injections. A micrometer-scale 3-D printed water-in-oil droplet generator device includes an oil phase inlet channel, an aqueous phase inlet channel, a droplet flow outlet channel, and two embedded non-contact electrodes. The inlet and outlet channels are connected internally at a junction. The electrodes comprise gallium metal injected within the 3-D printed device. Voltage across the electrodes generates water-in-oil droplets, determines a rate for a series of droplets, or triggers a phase shift in the droplets. An external trigger generates the droplets based on the frequency of an XFEL utilized in droplet detection, thereby synchronizing a series of droplets with x-ray pulses for efficient crystal detection. The generated droplets can be coupled to an SFX with XFEL experiment compatible with common liquid injector such as a GDVN.
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公开(公告)号：US11896971B2
公开(公告)日：2024-02-13
申请号：US17205016
申请日：2021-03-18
Applicant: Funai Electric Co., Ltd.
Inventor： Steven W. Bergstedt , Patricia A. Clore
CPC classification number: B01L3/0268 , B01L3/0241 , G01N35/1016 , B01L3/02 , G01N2035/1025 , G01N2035/1041
Abstract: A fluid ejection head and a method of detecting the presence of fluid in an ejection chamber. The ejection head includes a semiconductor substrate having an elongate fluid supply via etched therethrough. An array of fluid ejectors is disposed adjacent to the fluid supply via, wherein the elongate fluid supply via provides fluid to the array of fluid ejectors for ejection of fluid from the ejection head. Fluid sense cells for the array of fluid ejectors are disposed at each end of the fluid supply via, wherein each of the fluid sense cells has a fluid ejector, an electrode disposed in a fluid chamber for the fluid ejector, and an electrode disposed in a fluid channel associated with a fluid chamber. A fluid detection circuit is provided in electrical communication with each of the fluid sense cells for detecting the presence or absence of fluid in the fluid chamber.
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公开(公告)号：US11745176B2
公开(公告)日：2023-09-05
申请号：US17352848
申请日：2021-06-21
Applicant: Bottle Barons, LLC
Inventor： Benjamin Alan Ganter
CPC classification number: B01L3/0282 , B01L3/021 , B01L3/0241 , B01L3/0272 , B65D47/18 , B01L2200/0615 , B01L2200/087 , B01L2400/0406
Abstract: In various implementations, a dropper for a bottle may include a bulb with a flange and an extended leg. The dropper may be used as a cap, in some implementations, with or without a skirt. The dropper may inhibit leaks from a bottle when the dropper is used as a cap for the bottle.
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公开(公告)号：US20230173491A1
公开(公告)日：2023-06-08
申请号：US18161643
申请日：2023-01-30
Applicant: 10x Genomics, Inc.
Inventor： Rajiv BHARADWAJ , Anthony MAKAREWICZ , Bill Kengli LIN
IPC: B01L3/00 , G01N33/543 , B01F23/41 , B01F25/314 , B01F31/80 , B01F33/3011 , B01F33/302 , B01L3/02 , C12Q1/6806 , G01N33/58
CPC classification number: B01L3/502784 , B01L3/502761 , G01N33/54313 , B01F23/41 , B01F23/4105 , B01F25/3141 , B01F25/31422 , B01F25/31423 , B01F31/84 , B01F33/3011 , B01F33/3021 , B01L3/0241 , B01L3/50273 , C12Q1/6806 , G01N33/58 , B01L2300/0851 , B01L2300/161 , B01L2200/0652 , B01L2400/086 , B01L2200/0673 , B01L2200/0647 , C12Q1/686
Abstract: Devices, systems, and their methods of use, for generating droplets are provided. One or more geometric parameters of a microfluidic channel can be selected to generate droplets of a desired and predictable droplet size.
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Patent Agency Ranking
公开(公告)号：US20180272333A1
公开(公告)日：2018-09-27
申请号：US15889807
申请日：2018-02-06
Applicant: TOSHIBA TEC KABUSHIKI KAISHA
Inventor： Masaaki HIGUCHI , Seiya SHIMIZU , Ryutaro KUSUNOKI , Shuhei YOKOYAMA
IPC: B01L3/02
CPC classification number: B01L3/0241 , B01L3/0268 , B01L2200/021 , B01L2200/0621 , B01L2200/143 , B01L2300/0829 , B01L2300/10 , B01L2400/0487 , B41J2/14201 , B41J2/16579 , B41J2202/15 , G01N2035/1041
Abstract: According to one embodiment, a droplet dispensing apparatus includes a droplet ejection array having a plurality of nozzles from which droplets can be ejected into a well opening of a microplate plate on a baseplate, the plurality of nozzles being arranged in columns in a first direction and rows in a second direction that intersects the first direction, a light emitting unit configured to emit light having polarization perpendicular to a third direction oblique with respect to the first direction and the second direction, and a light receiving unit configured to receive light from the light emitting unit, the light receiving unit being on an opposite side of the droplet ejection array from the light emitting unit.
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公开(公告)号：US20180250677A1
公开(公告)日：2018-09-06
申请号：US15754754
申请日：2016-09-06
Applicant: SPHERE FLUIDICS LIMITED
Inventor： Xin LI , Xin Liu , Alexandra Clay
CPC classification number: B01L3/502776 , B01L3/0241 , B01L3/502715 , B01L3/502784 , B01L2200/0647 , B01L2200/0673 , B01L2300/0816 , B01L2300/0867 , B01L2300/161 , B01L2400/0463 , B01L2400/0487
Abstract: A microfluidic structure for spacing out and aligning entities in an aqueous suspension is provided. The structure comprises: a channel for guiding entities in an aqueous suspension; a first comb of first inlets arranged on a first side of the channel for introducing a spacing medium into the channel; and a second comb of second inlets arranged on a second side of the channel for introducing the spacing medium into the channel; wherein the first side is opposite the second side, and wherein one of the first inlets has a corresponding, respective one of the second inlets at a substantially similar longitudinal position along the channel.
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8.发明申请公开(公告)号：US20180015472A1
公开(公告)日：2018-01-18
申请号：US15717840
申请日：2017-09-27
Applicant: 10X Genomics, Inc.
Inventor： Rajiv Bharadwaj , Kevin Ness , Debkishore Mitra , Donald Masquelier , Anthony Makarewicz , Christopher Hindson , Benjamin Hindson , Serge Saxonov
CPC classification number: B01L3/502761 , B01L3/0241 , B01L3/502784 , B01L2200/0673 , B01L2300/0816 , B01L2400/049 , B01L2400/086 , G01N35/085 , G01N2035/00237 , G01N2035/1034
Abstract: The disclosure provides devices, systems and methods for the generation of encapsulated reagents and the partitioning of encapsulated reagents for use in subsequent analyses and/or processing, such as in the field of biological analyses and characterization.
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9.发明申请公开(公告)号：US20170348691A1
公开(公告)日：2017-12-07
申请号：US15596754
申请日：2017-05-16
Applicant: 10X Genomics, Inc.
Inventor： Rajiv Bharadwaj , Kevin Ness , Debkishore Mitra , Donald Masquelier , Anthony Makarewicz , Christopher Hindson , Benjamin Hindson , Serge Saxonov
CPC classification number: B01L3/502761 , B01L3/0241 , B01L3/502784 , B01L2200/0673 , B01L2300/0816 , B01L2400/049 , B01L2400/086 , G01N35/085 , G01N2035/00237 , G01N2035/1034
Abstract: The disclosure provides devices, systems and methods for the generation of encapsulated reagents and the partitioning of encapsulated reagents for use in subsequent analyses and/or processing, such as in the field of biological analyses and characterization.
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公开(公告)号：US20170307502A1
公开(公告)日：2017-10-26
申请号：US15491719
申请日：2017-04-19
Applicant: Becton, Dickinson and Company
Inventor： Clark Mason , Timothy W. Petersen , Vladimir Azersky , Christopher J. Wolf
CPC classification number: G01N15/14 , B01J19/0046 , B01J2219/00317 , B01J2219/00547 , B01J2219/00572 , B01J2219/00648 , B01J2219/00743 , B01L3/0241 , B01L3/5085 , B01L2200/0642 , B01L2200/0652 , B01L2300/0627 , B01L2300/0819 , B01L2300/0829 , B01L2300/0893 , C12M47/04 , G01N15/1404 , G01N15/1459 , G01N2015/1006 , G01N2015/1415
Abstract: Disclosed herein are methods for producing high density cellular arrays. In some embodiments, the methods comprise: providing a sample comprising a plurality of cells; and introducing the plurality of cells in the sample into microwells of a microwell array to produce a cellular array, wherein the microwell array comprises 500 or more microwells per inch2, and wherein 25% or more of the microwells of the cellular array comprise a single cell. The disclosed methods can be used for producing a high density synthetic particle array and a high density reagent array.
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