公开(公告)号：US20190178822A1

公开(公告)日：2019-06-13

申请号：US16328262

申请日：2018-05-22

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Alexandra ROS ,  Gerrit BREHM ,  Garrett NELSON ,  John SPENCE ,  Uwe WEIERSTALL ,  Austin ECHELMEIER

IPC: G01N23/2005 ,  B01F13/00 ,  B33Y80/00 ,  G01N23/20025 ,  B01L3/00

CPC classification number: G01N23/2005 ,  B01F13/0062 ,  B01F2215/0037 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2300/0867 ,  B33Y80/00 ,  G01N23/20025 ,  G01N2223/602 ,  G01N2223/604

Abstract: A 3D printed hybrid nozzle device combining a microfluidic mixer with a liquid jet injector that addresses the bottleneck of investigating substrate-initiated biological reaction paths employing serial crystallography with XFELs. The hybrid nozzle provides for injecting aqueous protein crystal jets after fast mixing (