公开(公告)号：US10557807B2

公开(公告)日：2020-02-11

申请号：US16328262

申请日：2018-05-22

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Alexandra Ros ,  Gerrit Brehm ,  Garrett Nelson ,  John Spence ,  Uwe Weierstall ,  Austin Echelmeier

IPC: G01N23/2005 ,  B01F13/00 ,  B33Y80/00 ,  G01N23/20025 ,  B01L3/00

Abstract: A 3D printed hybrid nozzle device combining a microfluidic mixer with a liquid jet injector that addresses the bottleneck of investigating substrate-initiated biological reaction paths employing serial crystallography with XFELs. The hybrid nozzle provides for injecting aqueous protein crystal jets after fast mixing (