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1.
公开(公告)号:US20180258416A1
公开(公告)日:2018-09-13
申请号:US15915909
申请日:2018-03-08
IPC分类号: C12N15/10 , B01J20/291 , B01D15/38
CPC分类号: C12N15/101 , B01D15/3804 , B01J20/291 , B01J2220/80
摘要: Ligands and methods for selectively binding hypermethylated DNA from a sample. The ligands include a CG-region binding molecule-conjugated resin derived from the aminoglycoside antibiotic amikacin. Furthermore, the CG-region binding molecule may be conjugated to the resin with a crosslinker and/or may be modified with one or more of long chain and short chain alkyl, aryl, piperazinyl, piperidyl, and pyrrolidyl groups. Such ligands are used in methods for contacting a sample to thereby selectively bind hypermethylated DNA.
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公开(公告)号:US10907145B2
公开(公告)日:2021-02-02
申请号:US15915909
申请日:2018-03-08
IPC分类号: C12N15/10 , B01D15/38 , B01J20/291
摘要: Ligands and methods for selectively binding hypermethylated DNA from a sample. The ligands include a CG-region binding molecule-conjugated resin derived from the aminoglycoside antibiotic amikacin. Furthermore, the CG-region binding molecule may be conjugated to the resin with a crosslinker and/or may be modified with one or more of long chain and short chain alkyl, aryl, piperazinyl, piperidyl, and pyrrolidyl groups. Such ligands are used in methods for contacting a sample to thereby selectively bind hypermethylated DNA.
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