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公开(公告)号:US10232345B2
公开(公告)日:2019-03-19
申请号:US15547173
申请日:2016-02-12
摘要: Methods and materials for the generation of amikacin antibiotic-derived microbeads, (FIG. 3). These beads may function as anion-exchange resins for use in pDNA purification as well as in situ capture of DNA from mammalian cells. New microresin and macroporous monolith based materials also are disclosed and may function for plasmid DNA binding and purification, mammalian whole cell genomic DNA extraction, and in-vitro cell culture.
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2.
公开(公告)号:US20180258416A1
公开(公告)日:2018-09-13
申请号:US15915909
申请日:2018-03-08
IPC分类号: C12N15/10 , B01J20/291 , B01D15/38
CPC分类号: C12N15/101 , B01D15/3804 , B01J20/291 , B01J2220/80
摘要: Ligands and methods for selectively binding hypermethylated DNA from a sample. The ligands include a CG-region binding molecule-conjugated resin derived from the aminoglycoside antibiotic amikacin. Furthermore, the CG-region binding molecule may be conjugated to the resin with a crosslinker and/or may be modified with one or more of long chain and short chain alkyl, aryl, piperazinyl, piperidyl, and pyrrolidyl groups. Such ligands are used in methods for contacting a sample to thereby selectively bind hypermethylated DNA.
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3.
公开(公告)号:US10428160B2
公开(公告)日:2019-10-01
申请号:US15645914
申请日:2017-07-10
申请人: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , BANNER HEALTH—an Arizona nonprofit corporation
摘要: An apparatus includes a hydrogel including a metallic compound, a surfactant, an acid, agarose and water. The hydrogel is substantially colorless. A radiated hydrogel having a color is formed when the hydrogel receives a low dose of ionizing radiation.
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公开(公告)号:US20190133685A1
公开(公告)日:2019-05-09
申请号:US16195121
申请日:2018-11-19
发明人: Kaushal Rege , Huang-Chiao Huang
IPC分类号: A61B18/20 , A61L24/10 , A61K38/18 , A61K38/19 , A61L24/00 , A61N5/06 , A61K41/00 , A61B18/18 , A61K38/39
摘要: Disclosed herein are methods of connecting disrupted tissue, tissue repair, treating colorectal disorder and tissue welding. The methods comprise using a bioadhesive composition comprising ELP and light absorbing chromophores and irradiating the bioadhesive tissue.
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公开(公告)号:US20220071613A1
公开(公告)日:2022-03-10
申请号:US17416240
申请日:2019-12-19
发明人: Kaushal Rege , Ridha Inam , Yu Yao
摘要: A method of closing an opening in a tissue comprises providing a light absorbing material, introducing the light absorbing material into a tissue opening, and irradiating the light absorbing material with at least one light source so as to increase a temperature of the light absorbing material, causing the tissue edges of the tissue opening adhere to the light absorbing material and/or to each other. A kit comprising a light absorbing material and a light emitting device is also described.
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公开(公告)号:US10907145B2
公开(公告)日:2021-02-02
申请号:US15915909
申请日:2018-03-08
IPC分类号: C12N15/10 , B01D15/38 , B01J20/291
摘要: Ligands and methods for selectively binding hypermethylated DNA from a sample. The ligands include a CG-region binding molecule-conjugated resin derived from the aminoglycoside antibiotic amikacin. Furthermore, the CG-region binding molecule may be conjugated to the resin with a crosslinker and/or may be modified with one or more of long chain and short chain alkyl, aryl, piperazinyl, piperidyl, and pyrrolidyl groups. Such ligands are used in methods for contacting a sample to thereby selectively bind hypermethylated DNA.
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7.
公开(公告)号:US20180066074A1
公开(公告)日:2018-03-08
申请号:US15645914
申请日:2017-07-10
发明人: Kaushal Rege
CPC分类号: C08B37/0039 , C01G7/00 , C08J3/075 , C08J2305/12 , C08K3/08 , C08K3/30 , C08K5/1535 , C08K2003/0831 , C08K2003/3009 , C08L5/12 , G01J3/00 , G01T1/04
摘要: An apparatus includes a hydrogel including a metallic compound, a surfactant, an acid, agarose and water. The hydrogel is substantially colorless. A radiated hydrogel having a color is formed when the hydrogel receives a low dose of ionizing radiation.
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公开(公告)号:US20220273365A1
公开(公告)日:2022-09-01
申请号:US17637484
申请日:2020-08-27
申请人: Arizona Board of Regents on behalf of Arizona State University , MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人: Kaushal Rege , Inam Ridha , Russell Urie , Pelagia Kouloumberis , Shelley Noland
摘要: The present invention provides a method of nerve repair using localized delivery of heat. The method involves localized induction of hyperthermia for end-to-end attachment of severed peripheral nerves by delivering stimulus responsive materials and exposing them to an excitation source under conditions wherein they emit heat. The generation of heat effects the joining of the nerve ends.
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公开(公告)号:US11317968B2
公开(公告)日:2022-05-03
申请号:US16195121
申请日:2018-11-19
发明人: Kaushal Rege , Huang-Chiao Huang
IPC分类号: A61B18/20 , A61B18/18 , A61L24/10 , A61K38/18 , A61K38/19 , A61L24/00 , A61K41/00 , A61K38/39 , A61N5/06 , A61N5/067 , A61B18/14 , A61B18/00
摘要: Disclosed herein are methods of connecting disrupted tissue, tissue repair, treating colorectal disorder and tissue welding. The methods comprise using a bioadhesive composition comprising ELP and light absorbing chromophores and irradiating the bioadhesive tissue.
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公开(公告)号:US20210100927A1
公开(公告)日:2021-04-08
申请号:US17065283
申请日:2020-10-07
发明人: Kaushal Rege , Deepanjan Ghosh
IPC分类号: A61L15/44 , A61L15/20 , A61L15/32 , A61K38/39 , A61P17/02 , A61K38/18 , A61K33/242 , A61N5/06 , A61K31/417 , A61L15/18 , A61K9/70
摘要: A wound dressing includes: a structural material formed into a dressing; at least one immunomodulatory agent associated with the dressing; and a growth factor associated with the dressing. A wound dressing kit includes: a structural material formed into a wound dressing; an immunomodulatory agent; and a growth factor composition, wherein the structural material contains the immunomodulatory agent and/or the immunomodulatory agent is in a separate composition. A method of treating a wound in a tissue includes: applying an immunomodulatory agent to the wound; applying a wound dressing to the wound; and allowing the wound to heal with the immunomodulatory agent and wound dressing. The application of a growth factor can be before, during and/or after applying the wound dressing to the wound.
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