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公开(公告)号：US20190234962A1
公开(公告)日：2019-08-01
申请号：US16116592
申请日：2018-08-29
Inventor： Stephen Johnston , Kurt Whittemore , Phillip Stafford , Lu Wang
CPC classification number: G01N33/6854 , G01N33/6848 , G16H50/20 , G16H50/50 , G16H50/80
Abstract: In certain embodiments, the present invention provides methods and compositions to measure unbiasedly the immune health status of an individual or population. A number of measures, including Shannon's entropy, can provide a measure of the diversity and disorder in the population of antibodies in a subject. The measure can be established by reacting the population of antibodies in a subject's blood with a complex surface, such as a peptide array.
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公开(公告)号：US20170343541A1
公开(公告)日：2017-11-30
申请号：US15621877
申请日：2017-06-13
Inventor： Stephen Albert JOHNSTON , Phillip Stafford
IPC: G01N33/543 , C40B40/10 , G01N33/53 , G01N33/68
Abstract: The invention provides arrays of compound for use in profiling samples. The arrays include compounds bind to components of the samples at relatively low affinities. The avidity of compounds binding to components of the samples can be increased by forming arrays such that multivalent components of the samples (e.g., antibodies or cells) can bind to more than one molecule of a compound at the same time. When a sample is applied to an array under such conditions, the compounds of the array bind to component(s) of the sample with significantly different avidities generating a profile characteristic of the sample.
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Patent Agency Ranking
公开(公告)号：US09709558B2
公开(公告)日：2017-07-18
申请号：US13624386
申请日：2012-09-21
Inventor： Stephen Albert Johnston , Phillip Stafford
IPC: G01N33/53 , G01N33/543 , C40B40/10 , C40B30/04 , G01N33/558 , G01N33/68
CPC classification number: G01N33/543 , C40B40/10 , G01N33/53 , G01N33/54306 , G01N33/6845 , G01N33/6854
Abstract: The invention provides arrays of compound for use in profiling samples. The arrays include compounds bind to components of the samples at relatively low affinities. The avidity of compounds binding to components of the samples can be increased by forming arrays such that multivalent components of the samples (e.g., antibodies or cells) can bind to more than one molecule of a compound at the same time. When a sample is applied to an array under such conditions, the compounds of the array bind to component(s) of the sample with significantly different avidities generating a profile characteristic of the sample.
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公开(公告)号：US11067582B2
公开(公告)日：2021-07-20
申请号：US16748723
申请日：2020-01-21
Inventor： Neal Woodbury , Stephen Johnston , Phillip Stafford
IPC: G01N33/68
Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.
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公开(公告)号：US10578623B2
公开(公告)日：2020-03-03
申请号：US15991892
申请日：2018-05-29
Inventor： Neal Woodbury , Stephen Johnston , Phillip Stafford
IPC: G01N33/68
Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.
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公开(公告)号：US10416174B1
公开(公告)日：2019-09-17
申请号：US15795134
申请日：2017-10-26
Applicant: Arizona Board of Regents on Behalf of Arizona State University , Whittemore Peterson Institute
Inventor： Stephen Albert Johnston , Phillip Stafford , Vincent Lombardi
Abstract: Described herein are methods and devices for diagnosing chronic fatigue syndrome using peptide arrays, and providing a prognosis to patients.
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公开(公告)号：US10006919B2
公开(公告)日：2018-06-26
申请号：US14773750
申请日：2014-03-14
Inventor： Neal Woodbury , Stephen Johnston , Phillip Stafford
IPC: G01N33/68
CPC classification number: G01N33/6845
Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.
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