公开(公告)号：US20250090567A1

公开(公告)日：2025-03-20

申请号：US18727665

申请日：2023-01-10

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Hao YAN ,  Yang XU ,  Xiaodong QI ,  Guangbao YAO ,  Chen GONG ,  Yung CHANG ,  Theresa YIP

IPC: A61K31/7088 ,  A61K31/443 ,  A61K31/513 ,  A61K31/7072 ,  A61K45/06 ,  A61P35/00

Abstract: Described herein are compositions comprising RNA origami (RNAOG) which include 5-fluorouracil (5FU) or analogues thereof are described which can be used to both directly treat a cancer by inhibiting a biochemical pathway overexpressed in a cancer cell and indirectly treat a cancer by inducing an anti-cancer immune response. Also described herein are methods of using said compositions for treating cancer, inducing an anti-cancer immune response, and/or killing a cancer cell.