公开(公告)号：US20200182874A1

公开(公告)日：2020-06-11

申请号：US16743906

申请日：2020-01-15

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  NATIONAL CANCER INSTITUTE

发明人： Joshua LaBaer ,  Jie Wang ,  Ji Qui ,  Garrick Wallstrom ,  Karen Anderson ,  Jin Park ,  Jonine Figueroa

IPC分类号： G01N33/574 ,  C12Q1/6886 ,  C07K16/30 ,  G01N33/564

摘要： Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).

公开(公告)号：US11525831B2

公开(公告)日：2022-12-13

申请号：US16743906

申请日：2020-01-15

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Joshua LaBaer ,  Jie Wang ,  Ji Qui ,  Garrick Wallstrom ,  Karen Anderson ,  Jin Park ,  Jonine Figueroa

IPC分类号： G01N33/564 ,  G01N33/574 ,  C07K16/30 ,  C12Q1/6886 ,  C12N15/11

摘要： Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).