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公开(公告)号：US20200182874A1
公开(公告)日：2020-06-11
申请号：US16743906
申请日：2020-01-15
发明人： Joshua LaBaer , Jie Wang , Ji Qui , Garrick Wallstrom , Karen Anderson , Jin Park , Jonine Figueroa
IPC分类号： G01N33/574 , C12Q1/6886 , C07K16/30 , G01N33/564
摘要： Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).
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公开(公告)号：US20200010899A1
公开(公告)日：2020-01-09
申请号：US16532138
申请日：2019-08-05
发明人： Joshua LaBaer , Kristin Gillis , Garrick Wallstrom , Jin Park , Vel Murugan , Mitch Magee
IPC分类号： C12Q1/6883
摘要： Disclosed herein are compositions and methods for accurately estimating the absorbed dose of radiation indicated by a subject based on the expression pattern of a panel of radiation-modulated (RM) genes at various time points following exposure of the subject to ionizing radiation.
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公开(公告)号：US20230079737A1
公开(公告)日：2023-03-16
申请号：US17940883
申请日：2022-09-08
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE U.S.A., AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Joshua LaBaer , Jie Wang , Ji Qiu , Garrick Wallstrom , Karen Anderson , Jin Park , Jonine Figueroa
IPC分类号： G01N33/574 , G01N33/564 , C07K16/30 , C12Q1/6886
摘要： Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).
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公开(公告)号：US20190004051A1
公开(公告)日：2019-01-03
申请号：US16069111
申请日：2017-01-11
发明人： Joshua Labaer , Ji Qiu , Jie Wang , Garrick Wallstrom , Jin Park , William Rom , Harvey Pass
IPC分类号： G01N33/574
摘要： An immune-proteomic screening of AAb responses using protein arrays has identified two panels of Aab (antigen/antibody complexes) that can potentially differentiate lung adenocarcinoma from smoker controls as well as CT positive benign lung disease. The resulting biomarkers appear to have high specificity so that high risk subjects with a positive CT screen and a positive serum test should get more invasive test such as needle biopsy for a timely cancer diagnosis, among other advantages.
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公开(公告)号：US11525831B2
公开(公告)日：2022-12-13
申请号：US16743906
申请日：2020-01-15
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Joshua LaBaer , Jie Wang , Ji Qui , Garrick Wallstrom , Karen Anderson , Jin Park , Jonine Figueroa
IPC分类号： G01N33/564 , G01N33/574 , C07K16/30 , C12Q1/6886 , C12N15/11
摘要： Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).
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公开(公告)号：US11243208B2
公开(公告)日：2022-02-08
申请号：US16317184
申请日：2017-07-11
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
IPC分类号： G01N31/00 , G01N33/53 , G01N33/574
摘要： Compositions and methods relating to a panel of antigen biomarkers for the early detection of ovarian cancer. The compositions and methods encompass antigen biomarkers coupled to a substrate, with the biomarkers being selected from the group consisting of one or more of ICAM3, CTAG2, p53, STYXL1, PVR, POMC, NUDT11, TRIM39, UHMK1, KSR1, and NXF3.
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公开(公告)号：US20190302122A1
公开(公告)日：2019-10-03
申请号：US16317184
申请日：2017-07-11
申请人： Benjamin KATCHMAN , Karen ANDERSON , Garrick WALLSTROM , Joshua LABAER , Daniel CRAMER , ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
IPC分类号： G01N33/574
摘要： Compositions and methods relating to a panel of antigen biomarkers for the early detection of ovarian cancer. The compositions and methods encompass antigen biomarkers coupled to a substrate, with the biomarkers being selected from the group consisting of one or more of ICAM3, CTAG2, p53, STYXL1, PVR, POMC, NUDT11, TRIM39, UHMK1, KSR1, and NXF3.
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公开(公告)号：US20170363631A1
公开(公告)日：2017-12-21
申请号：US15534203
申请日：2015-12-09
发明人： Joshua LaBaer , Jie Wang , Ji Qiu , Garrick Wallstrom , Karen Anderson , Jin Park , Jonine Figueroa
IPC分类号： G01N33/574 , C12Q1/68 , C07K16/30 , C12N15/11
CPC分类号： G01N33/57415 , C07K16/3015 , C12N15/11 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N33/564
摘要： Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).
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公开(公告)号：US12085569B2
公开(公告)日：2024-09-10
申请号：US17940883
申请日：2022-09-08
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Joshua LaBaer , Jie Wang , Ji Qiu , Garrick Wallstrom , Karen Anderson , Jin Park , Jonine Figueroa
IPC分类号： G01N33/574 , C07K16/30 , C12Q1/6886 , G01N33/564 , C12N15/11
CPC分类号： G01N33/57415 , C07K16/3015 , C12Q1/6886 , G01N33/564 , C12N15/11 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).
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公开(公告)号：US20220163531A1
公开(公告)日：2022-05-26
申请号：US17563279
申请日：2021-12-28
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
IPC分类号： G01N33/574
摘要： Compositions and methods relating to a panel of antigen biomarkers for the early detection of ovarian cancer. The compositions and methods encompass antigen biomarkers coupled to a substrate, with the biomarkers being selected from the group consisting of one or more of ICAM3, CTAG2, p53, STYXL1, PVR, POMC, NUDT11, TRIM39, UHMK1, KSR1, and NXF3.
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