公开(公告)号：US20150211059A1

公开(公告)日：2015-07-30

申请号：US14577715

申请日：2014-12-19

Applicant: ARIZONA BOARD OF REGENTS on behalf of ARIZONA STATE UNIVERSITY

Inventor： Kevin REINHART ,  Stuart LINDSAY ,  Peiming ZHANG

IPC: C12Q1/68 ,  G01N27/447

CPC classification number: C07D235/24 ,  C12Q1/6869 ,  G01N27/447 ,  G01N27/44791 ,  G01N33/48721 ,  C12Q2565/631

Abstract: The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such as a carbon nanotube nanopore. More particularly, the invention is directed to such systems, devices and methods in which a newly translocated portion of the iopolymer forms a temporary electrical circuit between the nanotube nanopore and a second electrode, which may also be a nanotube. Further, the invention is directed to such systems, devices and methods in which the constriction is provided with a transnaionilized unit which, together with a newly translocated portion of the biopolymer, forms a temporary electrical circuit that can be used to characterize the portion of the biopolymer.

Abstract translation: 本发明涉及用于识别生物聚合物的系统，装置和方法，例如当DNA通过诸如碳纳米管纳米孔的收缩体时，DNA的链。 更具体地说，本发明涉及这样的系统，装置和方法，其中聚合物的新易位部分在纳米管纳米孔和也可以是纳米管的第二电极之间形成临时电路。 此外，本发明涉及这样的系统，装置和方法，其中收缩部设置有横穿电泳单元，其与生物聚合物的新易位部分一起形成临时电路，其可用于表征部分 生物聚合物。